Beta Blocker Therapy for Severe Traumatic Brain Injury
Not Applicable
- Conditions
- Health Condition 1: S065- Traumatic subdural hemorrhage
- Registration Number
- CTRI/2021/08/035637
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Patients who present within 24 hours of moderate and severe traumatic brain injury who have:
a)Glasgow Coma Scale (GCS) score of <=12
b)Age: 18 to 60 years
Exclusion Criteria
•Pre-existing condition
oHeart disease
oCardiac dysrhythmia
oAllergy to study drugs
•Brain-related
oPenetrating brain injury
oPre-existing brain dysfunction
•Physiologic
oSpinal cord injury
oMyocardial injury
oSevere liver disease
oCurrent use of β-blocker and/or α2-agonist
oWithdrawal of care expected in 48 h
•Demographic
oPrisoners
oPregnant women
oUnable to follow-up through final visit
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the efficacy of beta blockers in reducing the mortality of hospitalized severe traumatic brain injury (TBI) patientsTimepoint: AT the time of discharge from hospital and 3 and 6 months after trauma.
- Secondary Outcome Measures
Name Time Method â?¢To assess the improvement in dysautonomia clinically.Timepoint: 6 months;â?¢To determine the efficacy of beta blockers in improving the functional outcomes and the quality of life of moderate and severe TBI patient at 6 months post injury <br/ ><br>Timepoint: 6 months