Surgical peri-implantitis treatment: regenerative approach and adjuvant antibiotic interventio
- Conditions
- Peri-implantitis
- Registration Number
- NL-OMON27505
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 123
the patient is =18 years of age;
- adult patients with at least one endosseous implant in the oral cavity with clinical and radiographical evidence of peri-implantitis. Peri-implantitis is defined as probing pocket depth (PPD) of = 6mm in combination with bleeding on probing (BOP) or suppuration on probing (SOP) and radiographic bone loss of =3mm after placing the definitive suprastructure (Berglundh et al. 2018);
- the implants have been in function for at least 2 years;
- the patient is capable of understanding and giving informed consent.
Exclusion criteria prior to pre-treatment:
- medical and general contra-indications for the procedure;
- a history of local radiotherapy to the head and neck region;
- pregnancy and lactation;
- uncontrolled diabetes mellitus (HbA1c <7% or <53 mmol/mol);
- use of intravenous bisphosphonates;
- known allergy to chlorhexidine, amoxicillin and/or metronidazole;
- long-term use of anti-inflammatory drugs
- patient is incapable of performing basic oral hygiene measures as a result of physical or mental disorders;
- implants with bone loss exceeding 2/3 of implant length or implants with bone loss beyond the transverse openings in hollow implants;
- previous surgical treatment of the peri-implantitis lesions;
- chronic bronchitis or asthma.
Additional exclusion criteria after pre-treatment:
- no peri-implantitis remaining: minor BoP (< 20%), PPD < 6mm, plaque < 20%;
- active periodontal disease at the remaining dentition (PPD = 6mm, BOP = 20%) or insufficient oral hygiene (plaque = 20%);
- use of antibiotics during the last 3 months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -Mean peri-implant bleeding on probing (BoP)
- Secondary Outcome Measures
Name Time Method