Effect of consumption of Cacao 72% dark chocolate for 4 weeks on blood pressure, fasting serum lipid profile, cognitive function, and markers of oxidative stress and inflammation in Japanese 45-69 subjects: single group pre-post trial
- Conditions
- Healthy Adults
- Registration Number
- JPRN-UMIN000022168
- Lead Sponsor
- Meiji Co., Ltd.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 400
Not provided
1. Persons who are currently medication for chronic disease 2. Persons who take pharmaceuticals, dairy supplement, health-promoting diet and health food for the purpose of health maintenance related to the test food of this trial within the last three months 3. Persons who were enrolled into other clinical trials within the last one month before agreeing to participate in this trial 4. Persons who are allergic to cacao products to the test food of this trial, milk protein, and soybean 5. Persons who took the cacao products daily in large quantity 6. Persons who are pregnant, or planning to get pregnant during the trial period 7. Persons who are lactating 8. Persons who are judged unsuitable for participating in this trial by physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood pressure (systolic blood pressure, diastolic blood pressure) and insulin resistance index (HOMA-IR, QUICKI) after 4 weeks of intervention
- Secondary Outcome Measures
Name Time Method Glucose, Insulin, Blood Lipid (Total cholesterol, HDL-Cholesterol, LDL-cholesterol, Triglyceride), Brain Derived Neurotrophic Factor Hs-CRP, 8-OHdG, SF-36