Evaluating Virechana and Hamsapathyadi Kashayam in Hypothyroidism- A Clinical and Computational Analysis
Phase 2
- Conditions
- Health Condition 1: E039- Hypothyroidism, unspecified
- Registration Number
- CTRI/2024/05/066907
- Lead Sponsor
- All India Institute of Ayurveda
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients between 21 to 60 years of age of either sex.
2.Patients with the symptomatology of hypothyroidism and elevated TSH.
3.Hypothyroid patients with associated Dyslipidemias [13][14].
4.Patients willing to participate in the trial.
Exclusion Criteria
1.Conditions contraindicated for Snehana and Virechana Procedure.
2.Any other thyroid pathology or any other endocrine disorders like DM, PCOS, Hyperparathyroidism, etc.
3.Pregnant females and breastfeeding mothers.
4.Any other major systemic illnesses like CAD, IHD, Arrhythmias, Vulvar Heart disease, CVA, Abnormal BP, Aortic Aneurysm, etc.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Part 1- <br/ ><br> <br/ ><br>Improvement in TSH level correction (Assumed value of TSH i.e., 7mIU/L would decline to 5.5mIU/L after the intervention) <br/ ><br> <br/ ><br>Part 2- <br/ ><br>Positive computational outcomes of Hamsapathyadi kashayam’s stimulatory effects on THRa & THRß. <br/ ><br>Timepoint: To be assessed thrice at 0th, 49th, 98th day
- Secondary Outcome Measures
Name Time Method 1.Improvement in clinical features of hypothyroidism. <br/ ><br>2.Improvement in lipid profile in Hypothyroidism-mediated dyslipidemias through- <br/ ><br>HDL lower than 40 mg/dL <br/ ><br>TC more than 200 mg/dL <br/ ><br>TG more than 140 mg/dL <br/ ><br>TC/HDL more than 05 <br/ ><br>3.Improvement in Apo-B levels hence lowering risk factors for atherosclerotic changes and CVS accidents. <br/ ><br>4.Assessment of QOL of hypothyroid patients. <br/ ><br>Timepoint: Lipid profile- To be assessed thrice at 0th, 49th, 98th day <br/ ><br>apolipo-B- To be assessed thrice at 0th, 49th, 98th day <br/ ><br>QOL assessment- To be assessed thrice at 0th, 49th, 98th day