NCT05811546招募中不适用
Immunohistochemical Evaluation of DNA Methylation and Histone Modification in H. Pylori Associated Gastric Carcinoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Difference in DNMT1 and EZH2 expression.
研究概览
简要总结
The goal of this cross-sectional study is to evaluate epigenetic modifications in gastric carcinogenesis, mainly in H. pylori gastritis vs gastric carcinoma. The main question[s] it aims to answer are:
- How does H. pylori infection cause gastric cancer?
- Can DNA methylation and other epigenetic changes predict and affect the development of gastric cancer? Formalin-fixed-paraffin-embedded tissue specimens will be obtained and reviewed for comparison between epigenetic changes in H. pylori gastritis and gastric adenocarcinoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Resected specimens and endoscopic guided biopsies of intestinal type gastric carcinoma, H. Pylori associated gastritis, and non-H. Pylori gastritis with:
- •Available full clinical data: (age, sex, complaint, findings in clinical examination).
- •Full data of previous endoscopy and radiology.
排除标准
- •Cases of diffuse type gastric carcinoma.
- •Any case of gastric cancer, H. Pylori associated gastritis, non-H. Pylori gastritis, benign gastric lesions with missing clinical, endoscopic, radiologic or follow-up data.
- •Cases with no available H&E stained slides or formalin fixed paraffin embedded block.
结局指标
主要结局
Difference in DNMT1 and EZH2 expression.
时间窗: two years
Histopathological evaluation of routine H\&E slides and immunohistochemical markers to compare the intensity and extent of epigenetic changes in both H. Pylori associated gastritis and gastric carcinoma.
次要结局
未报告次要终点
研究者
Aliyah Soliman Ali
Pathology resident
Assiut University
研究点 (1)
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