Coherence Analyses in Hyperkinetic Movement Disorders

Completed

Conditions: dystonia
essential tremor.
Hyperkinetic movement disorders
Parkinson
10028037
10009720

Registration Number: NL-OMON42214

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

1. Patients with Dystonia (DYS) or Parkinson's Disease (PD) who will be treated with DBS, and Essential Tremor (ET) patients with DBS in which the stimulator will be replaced operatively.
2. 18 years and older.
3. life expectancy longer than one year

Exclusion Criteria

Any condition with a life expectancy less then 1 year, which would result in incomplete follow-up.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In all patients: Relation between LFP-EMG coherence and clinical effect of DBS<br /><br>quantified by the difference pre- and post-surgery on the specific movement<br /><br>disorder rating scales.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In DYS: Cortico-muscular (EEG-EMG), intra-muscular (EMG-EMG) coherence, and<br /><br>Burke-Fahn-Marsden dystonia rating scale (BFMDRS) values pre- and<br /><br>post-DBS-surgery.<br /><br>In PD: Cortico-muscular (EEG-EMG + accelerometer) coherence, intra-muscular<br /><br>(EMG-EMG), and tremor severity assessed with tremor items of the motor (third)<br /><br>part of the unified Parkinson's disease rating scale (UPDRS) values pre- and<br /><br>post-DBS-surgery.</p><br>