Effect of Monosodium Glutamate Supplementation on Gastric Emptying and Postprandial Nitrogen Kinetics

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: NaCl supplementation; Dietary Supplement: MSg supplementation

• Registration Number: NCT00862017
• Lead Sponsor: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Brief Summary

There are receptors to free glutamate in the oral cavity and stomach that may mediate effects of this amino acid on gastrointestinal physiology. The investigators hypothesize that a chronic supplementation of monosodium glutamate (MSG) could modulate gastric emptying and the further metabolism of dietary protein in healthy subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-04
• Status Verified: 2009-03
• Study First Submitted: 2009-03-13
• Study First Submitted QC: 2009-03-13
• Last Update Submitted: 2009-03-13
• Study First Posted: 2009-03-16
• Last Update Posted: 2009-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• BMI 23 to 28

Exclusion Criteria

• pregnancy
• allergy to milk protein
• gastrointestinal diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control	NaCl supplementation	-
MSG	MSg supplementation	Subjects receive a 6-d supplementation of MSG and are studied on the 7th day in the postprandial period following a standard meal ingestion with 2g MSG

Trial Locations

Locations (1)

Centre de recherche sur volontaires; 🇫🇷 Bobigny, France