Study to evaluate effectiveness of prophylactic topical nepafenac 0.1 percentage in maintaining transoperative mydriasis and preventing post operative macular edema in topical phacoemulsification cataract surgery

Following standard cataract surgery, impairment of vision may result from post-operative cystoid macular oedema (CMO). The purpose of the research is to assess the efficacy of preventive topical nepafenac (0.1%) in preventing post-operative macular edema following phacoemulsified cataract surgery & in preserving transoperative mydriasis. This 2-year study where the patients reporting to the Department OPD of Ophthalmology, undergoing the phacoemulsification cataract surgery will be part of the research. The study include 38 patients (two groups) & the study type is prospective, randomized, single-masked comparative study. For topical mydriatic usage, each treatment group will receive two doses of tropicamide 0.8% & phenylephrine 5% every fifteen minutes. Moreover, the nepafenac group received 4 doses starting an hour before surgery at a rate of only one drop once every fifteen minutes. Following surgery, all patients had a 4-week tapering period after receiving topical corticosteroid-antibiotic therapy (prednisolone + moxifloxacin) once for one hour for 15 days. One drop of nepafenac will be administered three times a day to the participants in the group being studied (the nepafenac group) starting the day before surgery & continued for six weeks following. Postoperative evaluations will be performed on the first day & Weeks 2 & 6 after surgery for all patients. Significant findings in the effectiveness of prophylactic tropical nepafenac is expected in the maintenance of transoperative mydriasis & prevention of post operative macular edema in the cataract surgery.