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Clinical Trials/NCT05860309
NCT05860309
Not yet recruiting
Not Applicable

Preoperative Versus Postoperative Ultrasound Guided Quadratous Lunborum Block for Postoperative Analgesia Following Open Nephrectomy, Acomparative Study

Ain Shams University1 site in 1 country100 target enrollmentJune 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Regional Blocks
Sponsor
Ain Shams University
Enrollment
100
Locations
1
Primary Endpoint
The time to first postoperative rescue analgesia.
Status
Not yet recruiting
Last Updated
2 years ago

Overview

Brief Summary

A multimodal analgesia regimen is suggested after nephrectomy, although some patients still report agonising pain. Regional anesthesia approaches may improve postoperative pain management and reduce the requirement for opioids after renal surgery.QLB provides early and rapid pain relief

Detailed Description

In the immediate postoperative period, nerve blocks are considered a type of multimodal analgesia and have recently been proposed as analgesic options for patients undergoing open nephrectomy . Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. The main barrier to early postoperative ambulation is postoperative pain, which also lengthens hospital stays and raises the risk of respiratory problems and venous thromboembolism. Therefore, strict perioperative pain management can have both immediate and long-term advantages . QLB provides early and rapid pain relief and allows early ambulation in certain patient populations. Multiple case studies also confirmed the QLB to be a rescue block after different surgical procedures. Complications associated with the performance of abdominal wall blocks are fortunately very rare. However, studies on the effect of anterior QLB on postoperative opioid consumption are scarce . Regional anesthesia is quickly moving toward using ultrasound guidance as the gold standard. The use of ultrasound has significant advantages over traditional treatments such as nerve stimulation and loss of resistance. The improved safety and efficacy that ultrasound brings to regional anaesthesia will help promote its use and realise the benefits that regional anaesthesia has over general anaesthesia, such as decreased morbidity and mortality, superior postoperative analgesia, cost-effectiveness, decreased postoperative complications and an improved postoperative course . The aim of the present study is to compare the effectiveness of ultrasound-guided preoperative to postoperative QLB on the postoperative pain scores after Radical nephrectomy.

Registry
clinicaltrials.gov
Start Date
June 2023
End Date
December 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Sanaa Farag Mahmoud Wasfy

assistant professor of anesthesia and intensive care

Ain Shams University

Eligibility Criteria

Inclusion Criteria

  • o Patients aged between 18 - 60 years old.
  • Both sexes.
  • Physical Status: ASA I and II.

Exclusion Criteria

  • o Refusal of procedure or participation in the study .
  • Physical status: ASA III or above .
  • Infection at site of injection.
  • Psychiatric illness .
  • CNS Diseases like epilepsy, stroke ...etc.
  • History or evidence of coagulopathy .
  • Allergies to drug used (Bupivacaine 0.5%).
  • Patients who suffered from allergy to local anesthetics .
  • Difficult visualization of the anatomy.

Outcomes

Primary Outcomes

The time to first postoperative rescue analgesia.

Time Frame: postoperative 24 hours

the first time patient ask for analgesia

Secondary Outcomes

  • total consumption of opioid in first 24 hours(first 24 hours postoperatively)

Study Sites (1)

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