跳至主要内容
临床试验/NCT05860309
NCT05860309已完成不适用

Preoperative Versus Postoperative Ultrasound Guided Quadratous Lunborum Block for Postoperative Analgesia Following Open Nephrectomy, Acomparative Study

Ain Shams University2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2023年7月29日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
2
主要终点
The time to first postoperative rescue analgesia.

研究概览

简要总结

A multimodal analgesia regimen is suggested after nephrectomy, although some patients still report agonising pain. Regional anesthesia approaches may improve postoperative pain management and reduce the requirement for opioids after renal surgery.QLB provides early and rapid pain relief

详细描述

In the immediate postoperative period, nerve blocks are considered a type of multimodal analgesia and have recently been proposed as analgesic options for patients undergoing open nephrectomy .

Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. The main barrier to early postoperative ambulation is postoperative pain, which also lengthens hospital stays and raises the risk of respiratory problems and venous thromboembolism. Therefore, strict perioperative pain management can have both immediate and long-term advantages .

QLB provides early and rapid pain relief and allows early ambulation in certain patient populations. Multiple case studies also confirmed the QLB to be a rescue block after different surgical procedures. Complications associated with the performance of abdominal wall blocks are fortunately very rare. However, studies on the effect of anterior QLB on postoperative opioid consumption are scarce .

Regional anesthesia is quickly moving toward using ultrasound guidance as the gold standard. The use of ultrasound has significant advantages over traditional treatments such as nerve stimulation and loss of resistance. The improved safety and efficacy that ultrasound brings to regional anaesthesia will help promote its use and realise the benefits that regional anaesthesia has over general anaesthesia, such as decreased morbidity and mortality, superior postoperative analgesia, cost-effectiveness, decreased postoperative complications and an improved postoperative course .

The aim of the present study is to compare the effectiveness of ultrasound-guided preoperative to postoperative QLB on the postoperative pain scores after Radical nephrectomy.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • o Patients aged between 18 - 60 years old.
  • Both sexes.
  • Physical Status: ASA I and II.

排除标准

  • o Refusal of procedure or participation in the study .
  • Physical status: ASA III or above .
  • Infection at site of injection.
  • Psychiatric illness .
  • CNS Diseases like epilepsy, stroke …etc.
  • History or evidence of coagulopathy .
  • Allergies to drug used (Bupivacaine 0.5%).
  • Patients who suffered from allergy to local anesthetics .
  • Difficult visualization of the anatomy.

研究组 & 干预措施

preoperative quadratous lumborum block

Active Comparator

patients weill recieve preoperative ultrasound guided quadratous lumborum block at lateral position before start of surgery after induction of general anesthesia

干预措施: quadratous lumborum block (Other)

postoperative quadratous lumborum block

Active Comparator

patients weill recieve postoperative ultrasound guided quadratous lumborum block at lateral position at the end of surgery before recovery from general anesthesua

干预措施: quadratous lumborum block (Other)

结局指标

主要结局

The time to first postoperative rescue analgesia.

时间窗: postoperative 24 hours

the first time patient ask for analgesia

次要结局

  • total consumption of opioid in first 24 hours(first 24 hours postoperatively)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Sanaa Farag Mahmoud Wasfy

assistant professor of anesthesia and intensive care

Ain Shams University

研究点 (2)

Loading locations...

相似试验

Preoperative Versus Postoperative Quadratous... | 临床试验