Discovery of Biomarkers for Intrinsic Radiation Sensitivity in Cancer Patients

Recruiting

• Conditions: Nasopharyngeal Cancer; Prostate Cancer; Other Cancer

• Registration Number: NCT04340024
• Lead Sponsor: National Cancer Centre, Singapore

Brief Summary

Patients with cancers that are sensitive to radiotherapy treatment and/or patients who have experienced severe acute/ late side effects to radiotherapy will be recruited to the study. Blood and/or matched tumour-normal tissue pairs will be collected. Blood and/or tissue samples will be processed and studied for genetic and biochemical markers that have potential to be used for predicting sensitivity to radiation.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09-30
• Study First Submitted: 2020-03-26
• Study First Submitted QC: 2020-04-06
• Study First Posted: 2020-04-09
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-30
• Last Update Posted: 2024-02-01
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• Patients with severe side effects from radiotherapy
• Patients with a type of cancer that is associated with sensitivity to radiotherapy

Exclusion Criteria

• Age of patient must be between 21 (inclusive) and 99 (exclusive)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify proteins that are associated with radiation sensitivity in tissue samples	Tissue is from archived sample	Immunohistochemistry will be used to detect protein expression
Change in immune profile of blood and tissue after radiation	Blood is taken at informed consent; tissue is from archived sample	Mass cytometry using CyTOF technology will be used to detect the immune cell population
To identify RNA expression pathways that are associated with radiation sensitivity in blood and tissue samples	Blood is taken at informed consent; tissue is from archived sample	RNA sequencing
To identify genes or molecular pathways that are associated with radiation sensitivity in blood and tissue samples	Blood is taken at informed consent; tissue is from archived sample	Whole exome sequencing, single nucleotide polymorphism (SNP) assays

Trial Locations

Locations (1)

National Cancer Center Singapore; 🇸🇬 Singapore, Singapore