Discovery of Biomarkers for Intrinsic Radiation Sensitivity in Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- To identify proteins that are associated with radiation sensitivity in tissue samples
研究概览
简要总结
Patients with cancers that are sensitive to radiotherapy treatment and/or patients who have experienced severe acute/ late side effects to radiotherapy will be recruited to the study. Blood and/or matched tumour-normal tissue pairs will be collected. Blood and/or tissue samples will be processed and studied for genetic and biochemical markers that have potential to be used for predicting sensitivity to radiation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with severe side effects from radiotherapy
- •Patients with a type of cancer that is associated with sensitivity to radiotherapy
排除标准
- •Age of patient must be between 21 (inclusive) and 99 (exclusive)
结局指标
主要结局
To identify proteins that are associated with radiation sensitivity in tissue samples
时间窗: Tissue is from archived sample
Immunohistochemistry will be used to detect protein expression
Change in immune profile of blood and tissue after radiation
时间窗: Blood is taken at informed consent; tissue is from archived sample
Mass cytometry using CyTOF technology will be used to detect the immune cell population
To identify genes or molecular pathways that are associated with radiation sensitivity in blood and tissue samples
时间窗: Blood is taken at informed consent; tissue is from archived sample
Whole exome sequencing, single nucleotide polymorphism (SNP) assays
To identify RNA expression pathways that are associated with radiation sensitivity in blood and tissue samples
时间窗: Blood is taken at informed consent; tissue is from archived sample
RNA sequencing
次要结局
未报告次要终点