Comaparison of cisatracurium muscle relaxant administered via two different moethods during surgical procedures under general anaesthesia

Phase 4

Completed

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/01/030232
• Lead Sponsor: Department of Anaesthesiology

Brief Summary

Muscle relaxants are an integral part ofadministering general anaesthesia in patients. Cisatracurium is a newer non-depolarizingskeletal muscle relaxant with an intermediate duration of action. We will be comparing effect of intermittent doses and continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy in regards to total dose of cisatracurium consumption. The study has 2 groups with sample size of 60 patients including both males and females of age 18-65 years and excluding patients who refuse to give consent, laparoscopic surgery converted to open cholecystectomy, pregnant patients, BMI >30, patients with neuromuscular disorder and patients taking drugs which interfere with neuromuscular blockade of the drug.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-01
• Study Completion: 2021-11-17
• Last Update Posted: 2022-05-21

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 1. Age group between 18-65 years of either gender.
• 2. ASA grade I and II.
• 3. Patients scheduled to undergo elective laparoscopic cholecystectomy surgery under general anaesthesia.

Exclusion Criteria

• 1. Laparoscopic cholecystectomy converted to open cholecystectomy.
• 2. Patients with body mass index more than 30 kg/m2.
• 3. Pregnant females.
• 4. Patients taking drugs which interfere with neuromuscular blockade before operation.
• 5. Patient refusal to give consent.
• 6. Patients with neuromuscular disorder.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare cisatracurium administration by continuous infusion or intermittent bolus injection in regards to total dose of cisatracurium consumption	Intraoperatively every 5 minutes till 30 minutes and every 10 minutes till end of surgery

Secondary Outcome Measures

Name	Time	Method
To compare hemodynamic changes and any side effects during general anaesthesia.	intraoperatively every 5 minutes till 30 minutes and every 10 minutes till end of surgery

Trial Locations

Locations (1)

GGS MEDICAL COLLEGE AND HOSPITAL; 🇮🇳 Faridkot, PUNJAB, India

GGS MEDICAL COLLEGE AND HOSPITAL

🇮🇳Faridkot, PUNJAB, India

DR DHRUVIKA CHAUDHRY

Principal investigator

9876891177

dhruvikachaudhry@gmail.com