The use of bronchodilators in people with recently acquired spinal cord injury

Not Applicable

Completed

• Conditions: acute spinal cord injury and effects of bronchodilators on spirometry measures; Respiratory - Other respiratory disorders / diseases; Respiratory - Asthma; Neurological - Other neurological disorders

• Registration Number: ACTRN12609000828224
• Lead Sponsor: Royal North Shore Hospital Spinal Research Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-09-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

People with tetraplegia or paraplegia above T4 acquired within 6 weeks of randomisation
Motor complete lesion (ie, American Spinal Injuries Association (ASIA)scale A or B with no zones of partial motor preservation)
Able to provide informed consent
No recent pre morbid history of asthma or premorbid use of bronchodilators
not ventilated
stable Vital capacity over preceeding 2 days OR stable respiratory status

Exclusion Criteria

Not medically stable, requiring ventilatory support with mechanical ventilation via endothracheal tube or tracheostomy
Premorbid recent history of asthma or bronchodilator use

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Peak expiratory flow and Forced expiratory volume 1 and Forced Vital Capacity with salbutamol compared to placebo[10 minutes post treatment];spirometry (Peak expiratory flow and Forced expiratory volume 1 and Forced Vital Capacity )[spirometry 30 minutes post administration]

Secondary Outcome Measures

Name	Time	Method
response to ventolin and placebo over 30 minutes measured with spirometry. Patients will be required to perform a forced vital capacity manouvere in supine prior to and then at 10 minutes 30 minutes post administration of ventolin or placebo. Best of three attempts will be taken.[10 minutes and 1 hour post administration]