Third MMR vaccine dose in young adults
Completed
- Conditions
- MMR vaccinationMumps, Measles and RubellaMumps outbreakImmunogenicity and toleranceAntibody response and cellular immunityBMR vaccinatieBof, Mazelen en Rode HondBof uitbraakImmunogeniciteit en veiligheidAntistof respons en cellulaire immuniteit
- Registration Number
- NL-OMON20600
- Lead Sponsor
- ational Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control (CIb)
- Brief Summary
https://pubmed.ncbi.nlm.nih.gov/33269296/ https://pubmed.ncbi.nlm.nih.gov/34211021/ https://pubmed.ncbi.nlm.nih.gov/31112277/
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
1. Healthy young adult 18-25 years of age
2. Previously been immunized with two doses of the MMR vaccine according to the Dutch
NIP (MMR-1 at ~14 months and MMR-2 at ~9 years)
Exclusion Criteria
1. Medical conditions that will severely affect immunological responses to vaccinations,
such as, but not limited to, cancer or an immune disorder.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary study parameters are the mumps-specific VN antibody concentrations<br>(against the vaccine- and currently circulating mumps virus strains) and IgG antibody<br>concentrations (including antibody avidity) measured in serum samples taken prior to,<br>and 10 days, 4 weeks, 1 year and 3 years following a third vaccine dose of MMR in healthy<br>young adults (18-25 years).
- Secondary Outcome Measures
Name Time Method -Frequency and intensity of the local and systemic adverse events<br /><br>- Mumps-specific IgA and IgG (saliva) prior to, and 4 weeks and 1 year following a third vaccine dose of MMR<br /><br>- The presence and frequency of mumps-specific memory and effector T- and B-cells in peripheral blood following MMR-3, in a voluntary subset of the participants prior to, 4 weeks and 1 year following a third vaccine dose of MMR<br /><br>-Serum IgG response against measles and rubella (components of the MMR vaccine)<br>prior to, 10 days, 4 weeks, 1 year and 3 years following a third vaccine dose of MMR