Intraoperative measurement of hepatic rigidity

Recruiting

• Conditions: K74.0; K74.1; C22.0; C78.7; K70; K73; K75; K76; Hepatic fibrosis; Hepatic sclerosis

• Registration Number: DRKS00021204
• Lead Sponsor: niversitätsklinik für Viszeralchirurgie - PIUS-Hospital Oldenburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Age of majority
- indicated laparotomy, if an adequate measurement can be made under the given surgical incision
- Period: April 2020 to April 2021

Exclusion Criteria

- Minority
- Cases outside the period from April 2020 to April 2021
- Insufficient knowledge of the German language
- Refusal to participate in the study
- Withdrawal at the request of the patient

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rigidity of healthy and abnormally changed livers in vivo in indicated laparotomies as well as ex vivo from resected parts of the liver, measured by durometer.

Secondary Outcome Measures

Name	Time	Method
- correlation between liver rigidity and the Hounsfield scale or values extracted from the MRI sequences<br>- correlation between liver rigidity and different liver-specific laboratory values (alanine aminotransferase (ALT, ALAT)/glutamate pyruvate transaminase (GPT), aspartate aminotransferase (AST)/glutamate oxaloacetate transaminase (GOT), gamma-glutamyltransferase (gamma-GT), alkaline phosphatase (AP), lactate dehydrogenase (LDH), alpha-foetoprotein (AFP), bilirubin (direct, indirect), quick value / INR, antithrombin, platelets, ammonia, albumin, cholinesterase, hepatitis serology, serum ferritin)<br>- Relation between liver hardness and liver diseases (hepatitis, HCC, liver cirrhosis, sclerosing cholangitis, alveolar echinococcosis, cystic echinococcosis)