Trial of the clinical and cost-effectiveness of a specialist expert mood disorder team for treating depressio

Not Applicable

Completed

• Conditions: Topic: Mental Health; Subtopic: Depression; Disease: Depression; Mental and Behavioural Disorders; Unipolar depressive disorder

• Registration Number: ISRCTN10963342
• Lead Sponsor: niversity of Nottingham

Brief Summary

2010 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/21114826 protocol 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27498098 results 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29902995 qualitative study results 2023 Results article in https://doi.org/10.1016/j.jad.2023.10.105 Follow up results (added 23/10/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2013-07-11
• Study Start: 2015-11-25
• Last Update Posted: 6 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 222

Inclusion Criteria

1. Aged over 18 years
2. Able and willing to give oral and written informed consent to participate in the study
3. Suffering from primary unipolar depression which is not a consequence of having another axis 1 or 2 psychiatric disorder
4. From the date of first assessment by a health professional working within the index mental health trust, primary care trust or third sector, they must have been offered or received direct and continuous care from one or more health professionals in the preceding 6 months. They must currently be under the care of a secondary care mental health team.
5. Meets NICE criteria for moderate depression (five out of nine symptoms of depression (NICE, 2004)); has a Hamilton Depression Rating Scale of at least 16; and score 60 or less on the Global Assessment of Functioning Scale (American Psychiatric Association, 1994).

Exclusion Criteria

1. Is receiving emergency care for suicide risk, risk of severe neglect or homicide risk. However, patients will not be excluded because of such risk provided the risk is adequately contained within their current care setting and the primary medical responsibility for care remains with the referring team.
2. Does not speak fluent English
3. Pregnancy (female participants)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression assessed using the Hamilton Depression Rating Scale at baseline, 6, 12, 18, 24 and 36 months

Secondary Outcome Measures

Name	Time	Method
Functional ability assessed using the Global Assessment of Functioning scale at baseline, 6, 12, 18, 24 and 36 months