Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and Manual Therapy in Patients With Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Osteoarthritis, Knee; Osteoarthritis
• Interventions: Dietary Supplement: Chondroitin Sulfate; Procedure: Resistance exercise training; Procedure: Manual therapy / Joint Mobilization; Procedure: THE therapy

• Registration Number: NCT04654871
• Lead Sponsor: Foundation University Islamabad

Brief Summary

Osteoarthritis (OA) IS one of the most common joint disorders, affecting not only the joints but also the surrounding muscles, which become weak. Resistance exercise reduces pain and improves function in patients with OA of the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used by patients with OA to reduce pain and thereby maintain the ability to perform daily activities. However, there is accumulating evidence for a negative effect of NSAIDs, thus many patients with OA are treated with dietary supplementations such as glucosamine and chondroitin sulfate, and some studies show a beneficial effects on cartilage and pain. However, their effect on OA symptoms and cartilage remains controversial. Thus, it is important to investigate whether a potentially beneficial effect of glucosamine and chondroitin sulfate with resistance exercise and manual therapy in patients with knee OA.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Primary Completion: 2020-09-01
• Study Completion: 2020-11-01
• Study First Submitted: 2020-11-26
• Status Verified: 2020-12
• Study First Submitted QC: 2020-12-03
• Last Update Submitted: 2020-12-03
• Study First Posted: 2020-12-04
• Last Update Posted: 2020-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• knee osteoarthritis for at least 3 months
• knee pain no more than 8/10
• Grade III or less on radiograph (Kellgren classification)

Exclusion Criteria

• Malignancy
• Any additional Inflammatory disorders
• Infection
• Knee trauma
• lower limb fracture
• Lumbar radiculopathy or myelopathy
• knee surgery or replacement
• Intra-articular steroid therapy in the last 2 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental Group	THE therapy	-
Experimental Group	Chondroitin Sulfate	-
Experimental Group	Manual therapy / Joint Mobilization	-
Active Comparator Group	Resistance exercise training	-
Active Comparator Group	Manual therapy / Joint Mobilization	-
Active Comparator Group	THE therapy	-
Experimental Group	Resistance exercise training	-

Primary Outcome Measures

Name	Time	Method
Visual Analogue Scale	4 weeks	Visual Analogue Scale was used to measure pain scoring from 0-10 cm on a horizontal 10cm line. A greater score reflects higher pain intensity.
Knee Joint Range of Motion	4 weeks	Knee Joint Range of Motion will be measured via goniometry. It is a continuous scale and a greater score reflects greater angular movement possible at the knee joint, which is measured in degrees.
Fall risk	4 weeks	Fall risk will be measured via Biodex balance system, and greater score reflects greater fall risk and poorer outcome.
5 repetition sit to stand test	4 weeks	Time will be measured to perform 5 repetitions of sit to stand activity. Lesser time means a better score.
Modified sphygmomanometer dynamometry	4 weeks	Modified sphygmomanometer dynamometry was used to measure muscle strength. Greater score will reflect greater muscle strength. The unit of Modified sphygmomanometer dynamometry used will be mmHg (millimeter of mercury).
Knee Injury and Osteoarthritis Outcome Score	4 weeks	Knee Injury and Osteoarthritis Outcome Score (KOOS) to measure physical function and quality of life. A greater score on Knee Injury and Osteoarthritis Outcome Score reflects good prognosis and outcome and a lower score shows poor prognosis and outcome. the score for Knee Injury and Osteoarthritis Outcome Score is reported in the form of percentage i.e. 0-100%.
Body Composition	4 weeks	Body Composition was measured via bioelectrical impedance analysis. A greater Phase angle reflects better cellular integrity and smaller phase angle reflects poorer cellular integrity.

Trial Locations

Locations (1)

Foundation University Institute of Rehabilitation Sciences.; 🇵🇰 Islamabad, Federal, Pakistan