Technetium-99m HMPAO granulocyte scintigraphy as a tool to measure inflammatory load in Ulcerative Colitis: a cross-sectional study
Completed
- Conditions
- Inflammatory Bowel Diseasehttps://toetsingonline.ccmo.nl/ccmomon.nsf/0/A1A4F7B322EF7BF6C12579EC003742B8?EditDocumentUlcerative Colitis10017969
- Registration Number
- NL-OMON37564
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
-Age from 18 years, either male or female
-Established diagnosis (endoscopic/histological proven) of ulcerative colitis with different severities of disease and irrespective of treatment
-Clinical Indication for coloscopy for assessment of disease activity
-Obtained written informed consent
-A completed Truelove Witts Index
Exclusion Criteria
-Toxic Megacolon, colon perforation
-Infectious disease (Positive stool culture)
-Pregnancy
-History of Colectomy
-Use of i.v. corticosteroids within the last 36 hours
-Renal Failure (eGFR<60)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the Summed Scintigraphic Activity Index (SSAI) of<br /><br>WBC scintigraphy (in correlation with endoscopy/histology).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary parameters are Mayo score by inclusion colonoscopy, biopsies, SCCAI<br /><br>(Simple Clinical Colitis Activity Index), CRP, Albumine and thrombocyte count<br /><br>and fecal calprotectin testing.</p><br>