Comparison Of mini-implant supported maxillary canine retraction with and without submucosal injection of autologous platelet rich plasma :A prospective ,single –blind ,split mouth randomized controlled trial.

The study is a Prospective ,Single-blind ,Randomized controlled trial with a Split-mouth design to evaluate the efficacy of submucosal injection of platelet rich plasma (PRP) for accelerating orthodontic tooth movement (OTM) in fixed orthodontic patients . The study will be conducted at the Department of orthodontics and dentofacial Orthopaedics (Bhojia dental collage and hospital ,Baddi). The study population will include subjects with permanent dentition of either gender between 16 and 25 years of age requiring bilateral extraction of maxillary first permanent molar as part of their comprehensive treatment. The inclusion criteria also specify critical anchorage ,adequate inter-radicular distance between maxillary first permanent molar and second premolar for insertion of mini screws , and good gingival and periodontal health . The intervention involves the application of fixed orthodontic brackets and extraction of maxillary first premolars for all patients. The principal investigator will be responsible for examining the subjects and determining their eligibility . The trial coordinator will evaluate the rate of canine retraction , and the follow-up process will involve assessing the subjects and analyzing the data. The study will be conducted according to the 1975 Helsinki declaration guidelines as revised in 2013 . statistical analysis will be done with SPSS version 22.0.