Comparisons of Two Airway Clearance Techniques

Not Applicable

Recruiting

• Conditions: Airway Clearance Impairment
• Interventions: Procedure: Chest physiotherapy; Procedure: high frequency chest wall oscillation

• Registration Number: NCT06032871
• Lead Sponsor: Hui-Ling Lin

Brief Summary

The goal of this clinical trial is to compare the effectiveness of two airway clearance techniques for patients with ventilator associated pneumonia. The main questions it aim to answer are:

* effect of the therapies on volume changes

* outcome on sputum clearance Participants will receive airway clearance techniques of

* chest physiotherapy

* high frequency chest wall oscillation.

Detailed Description

Sputum can be accumulated in the airways of intubated patients, resulting in recurrent pneumonia. The airway clearance therapy is often utilized with chest physiotherapy or high frequency chest wall oscillation which has become popular for its easy of use and less time consuming to the healthcare workers. The main questions it aim to answer are on effectiveness of the therapies on lung volume changes and sputum clearance by two airway clearance techniques. With the oscillation of entire chest wall, the investigators hypothesize that the high frequency chest wall oscillation is more effectively clear sputum in the distal airways.

Study Timeline

• Study Start: 2023-03-16
• Status Verified: 2023-09
• Study First Submitted: 2023-09-05
• Study First Submitted QC: 2023-09-05
• Last Update Submitted: 2023-09-12
• Study First Posted: 2023-09-13
• Last Update Posted: 2023-09-14
• Primary Completion: 2024-03-30
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Diagnosed with chronic pulmonary disease
• Diagnosed with ventilator associated pneumonia
• Receive airway clearance therapy

Exclusion Criteria

• Head injury, spinal injury
• Instable hemodynamics
• Intercranial pressure > 20 cmH2O
• Active hemoptysis
• Empyema
• Eye surgery
• Abdominal distension
• Chest tube insertion
• Active tuberculosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Chest physiotherapy	Chest physiotherapy	Patients receive airway clearance by chest physiotherapy for 30 minutes twice a day.
High frequency chest wall oscillation	high frequency chest wall oscillation	Participants received high frequency chest wall oscillation therapy twice a dy

Primary Outcome Measures

Name	Time	Method
end-expiratory lung impedance	Measurement before intervention, 30 after, 1 hour and 2 hours after intervention	Changes of global of impedance of lungs measure by the electrical impedance tomography

Secondary Outcome Measures

Name	Time	Method
Weight of secretions	Sputum is collected before intervention, 30 after, 1 hour and 2 hours after intervention	Sputum amount is weighted.

Trial Locations

Locations (2)

Linkou Chang Gung Memorial Hospital; 🇨🇳 Taoyuan, Taiwan

Chang Gung Memorial Hospital; 🇨🇳 Taoyuan, Taiwan