Carotid Artery Stenting during Endovascular treatment of acute ischemic Stroke: a randomized multicenter clinical trial in patients with acute ischemic stroke and carotid artery stenosis undergoing endovascular treatment

niversity Medical Center Groningen0 个研究点目标入组 600 人开始时间: 2023年1月18日最近更新: 2024年7月29日

适应症

试验速览

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•1. Acute ischemic stroke due to proximal intracranial occlusion in the anterior circulation (intracranial ICA, M1, proximal M2) on the CT angiography
•2. Stenosis >50% according to the NASCET criteria16 or initial occlusion of the ipsilateral cervical carotid artery of presumed atherosclerotic origin on baseline CT angiography
•3. Eligible for EVT according to the guidelines: EVT within 6 hours of onset or EVT between 6-24 hours after onset based on perfusion CT imaging selection (conform current guidelines)
•4. Baseline National Institute of Health Stroke Scale (NIHSS) score =2
•5. Age >18 years
•6. Written informed consent (deferred consent)

•1. Any intracranial hemorrhage
•2. Cervical carotid artery stenosis or occlusion with other causes than presumed atherosclerosis (e.g. carotid artery dissection, floating thrombus, carotid web)
•3. Any exclusion criterion for EVT according to the guidelines
•4. Pre stroke disability (defined as a modified Rankin Scale score >2)
•5. Recent gastro-intestinal or urinary tract hemorrhage (<6 weeks)
•6. Recent severe head trauma (<6 weeks)
•7. Recent infarction on baseline brain CT in the same vascular territory (<6 weeks)
•8. Known allergy to aspirin and/or clopidogrel
•9. Pregnancy

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