The Impact of Physical Activity on the Postoperative Symptoms, Complications, and Quality of Life Among Lung Cancer

Active, not recruiting

• Conditions: Lung Neoplasms

• Registration Number: NCT03705546
• Lead Sponsor: Samsung Medical Center

Brief Summary

The purpose of this study is to examine the impact of physical activity on the postoperative symptoms, complication, and quality of life.

Detailed Description

Non-small cell lung cancer (NSCLC) survivor is increasing as developing early diagnosis and perioperative management. Despite multidisciplinary treatment, Surgery is the primary treatment option for cure in NSCLC. The patients with lung cancer who underwent surgery have limitation of pulmonary function and high risk of co-morbidities. Perioperative physical activity has been shown to reduce symptoms and prevent complications, improve long term quality of life after surgery. But validated exercise regimen has not been established for lung cancer patients. Therefore, Evidence-based guideline focusing on lung cancer after surgery is needed.

Study Timeline

• Study Start: 2016-03-04
• Study First Submitted: 2018-10-05
• Study First Submitted QC: 2018-10-12
• Study First Posted: 2018-10-15
• Primary Completion: 2020-12-31
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-22
• Last Update Posted: 2024-05-24
• Study Completion: 2026-03-03

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1050

Inclusion Criteria

• Patients who are diagnosed with lung cancer
• Patients who are able to walk with ECOG (Eastern Cooperative Oncology Group) performance status < 1
• Patients who understand the purpose of this study and provide the written informed consent

Exclusion Criteria

• Patients who have difficulty for walking
• Patients with history of other cancer in the last 3 years
• Patients with neoadjuvant chemotherapy and/or radiation therapy
• Patients who are diagnosed with recurrent lung cancer or multiple cancer
• Foreigner of patients from overseas who are not able regularly participate in this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The change of quality of life: (EORTC QLQ) core30 (C30)	Before surgery (baseline), and 1, 6, 12, 24, 36, 48, and 60 months after surgery	The change of quality of life is measured using the European Organization for Research Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) core30 (C30). The scale for quality of life is transformed into a score from 0 to 100, derived by 4-point Likert scale. A higher score represents a higher level of quality of life.

Secondary Outcome Measures

Name	Time	Method
Postoperative pulmonary complications	Within 30 days after surgery	Incidence of pulmonary complications including air leak, atelectasis, pleural effusion, pneumonia, etc.
The change of symptom	Before surgery (baseline), and 1, 6, 12, 24, 36, 48, and 60 months after surgery	The change of symptom is measured using the European Organization for Research Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) lung cancer module 13 (LC13). The scale for symptom is transformed into a score from 0 to 100, derived by 4-point Likert scale. A higher score represents a higher level of symptom.

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of