The Active After Cancer Trial (AACT)

Not Applicable

Active, not recruiting

• Conditions: Breast Cancer; Colorectal Cancer
• Interventions: Behavioral: Telephone-Based exercise intervention

• Registration Number: NCT00548236
• Lead Sponsor: Dana-Farber Cancer Institute

Brief Summary

This study is being done to determine whether a telephone-based counseling intervention can help survivors of breast and colorectal cancer increase their weekly physical activity. Observational evidence suggests that physical activity after breast and colorectal cancer diagnosis decreases recurrence rates. Unfortunately, many people become less active during cancer therapy, and a substantial proportion never return to pre-diagnosis levels of physical activity. This study looks to see if people who have recently finished chemotherapy for breast, colon or rectal cancer can be motivated to increase their exercise by talking to an exercise specialist over the phone. The study also looks at changes in mood, fatigue, fitness, fat distribution and weight.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-10
• Study First Submitted: 2007-10-22
• Study First Submitted QC: 2007-10-22
• Study First Posted: 2007-10-23
• Primary Completion: 2009-03
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-22
• Last Update Posted: 2024-01-23
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Histologically confirmed stage I-III breast or colorectal cancer
• 18 years of age or older
• Completed adjuvant treatment(for current malignancy)
• Completion of all adjuvant chemotherapy and radiation (with the exception of adjuvant herceptin and/or tamoxifen/aromatase inhibitor therapy for breast cancer patients) between 2 and 36 months prior to enrollment
• Ability to speak and read English
• Willingness to be randomized
• Medical clearance from an oncologist or primary care physician stating the participant is able to participate in an unsupervised, moderate-intensity physical activity program
• No major surgery within 2 months of study enrollment or planned during study period

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Exclusion Criteria

• Metastatic cancer
• Uncontrolled intercurrent illness including, but not limited to, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness that would limit compliance with study requirements
• Plans to have hip or knee replacement within a year
• Participation in more than 60 minutes a week of moderate-intensity recreational activity as assessed by the International Physical Activity Questionnaire Short Form
• BMI >47

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Telephone-Based exercise intervention	Immediate participation in a 16-week exercise program

Primary Outcome Measures

Name	Time	Method
To evaluate the ability of a multi-center, telephone-based physical activity intervention to increase weekly physical activity levels in sedentary patients treated with adjuvant chemotherapy for Stage I-III breast or colorectal cancer.	months

Secondary Outcome Measures

Name	Time	Method
To evaluate the impact of a physical activity intervention upon fitness, exercise self-efficacy, anthropometric measures, and quality of life in a group of patients with stage I-III breast or colorectal cancer.	months

Trial Locations

Locations (9)

Ohio State University; 🇺🇸 Columbus, Ohio, United States

Vermont Cancer Center; 🇺🇸 Burlington, Vermont, United States

Dana-Farber Cancer Institute; 🇺🇸 Boston, Massachusetts, United States

University of California San Francisco; 🇺🇸 San Francisco, California, United States

Hematology Oncology Associates of Central New York; 🇺🇸 East Syracuse, New York, United States

University of California at San Diego; 🇺🇸 La Jolla, California, United States

Lakes Regional Healthcare Hematology Oncology; 🇺🇸 Hooksett, New Hampshire, United States

New Hampshire Oncology Hematology; 🇺🇸 Concord, New Hampshire, United States

Rosewell Park Cancer Institute; 🇺🇸 Buffalo, New York, United States