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临床试验/NCT04398563
NCT04398563Unknown不适用

Heart Failure in Norway: Combining Artificial Intelligence and a Database of 15000 Patients to Understand Clinical Characteristics, Mortality and Health Care Resource Use

University Hospital, Akershus1 个研究点 分布在 1 个国家目标入组 14,998 人开始时间: 2020年1月20日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
14,998
试验地点
1
主要终点
Mortality

研究概览

简要总结

The prevalence of Heart failure above 70 years of age is 10% and 5 year mortality rate above 60%, higher than for cancer. The readmission rate first after hospitalisation is 44% despite the availability of life prolonging and life quality enhancing treatment. There is a lack of resources for adequate diagnostic workup necessary for implementing evidence-based treatment. This projects aims at assessing the impact of guidelines based diagnostic workup and guidelines based treatment of heart failure on mortality and readmission rates. As the symptoms defining the degree of heart failure and the discharge medication only is available in the electronic patient files, artificial intelligence is used to retrieve this information to assess if treatment is according to guidelines.

The project is using first a rule based text processing approach using IBM Watson, then advancing to a machine learning approach using readmission and mortality as endpoints.

The project has access to digitally stored echocardiographic measurements as well as digital ECG's and lab data on 15 000 patients admitted with a diagnosis of Heart failure. If the retrieval of symptoms and function by artificial intelligence is successful, the next step is to assess if those benefitting the most from echocardiography can be identified using information from the ECG's, lab data or symptoms and functional capacity as described in the Electronic Health Records.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Diagnosis with ICD10 codes as follows; I50.*, I42.3, I11.* and COPD J44.* from 2007 through
  • In addition all subjects with NT-proBNP above age specific normal range in same period.

排除标准

  • 未提供

结局指标

主要结局

Mortality

时间窗: Change over 12 years

1 year mortality rate after first diagnosis of heart failure

Readmission

时间窗: Change over 12 years

30 days and 1 year readmission rate

次要结局

  • Diagnostic work up according to guidelines(Within 6 months before or after first diagnosis)
  • Treatment according to guidelines(within first year after first diagnosis)

研究者

发起方
University Hospital, Akershus
申办方类型
Other
责任方
Principal Investigator
主要研究者

Torbjorn Omland

Professor

University Hospital, Akershus

研究点 (1)

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