Early detection of dementia using brain perfusion SPECT with cognitive stress test
- Conditions
- mild cognitive impairment (MCI)mild cognitive impairmentearly detectiondementia screeningbrain imagingcognitive stressperfusion SPECT
- Registration Number
- TCTR20190811001
- Lead Sponsor
- Ratchadapiseksompotch Grant, Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 155
- Age 55 - 85 years
- No known history of uncontrolled psychiatric disease
- Stable controllable dementia without choline esterase inhibitor adjustment in the past 3 months
- Thai nationality
- Diseases which affect this study eg.chronic kidney disease (GFR<30 ml/min), chrnic liver disease (Child-Pugh class B), DM (HbA1c>=7mg% ), all types of cancer
- Who cannot perform CT or MRI of the brain
- Those who have dementia etiology from other causes eg. depression, cerebrovascular disease, etc.
- Patients with neurological disease that affects cognition eg. epilepsy, parkinson disease etc.
- Those who cannot read/write/speak Thai language.
- Those who have MRI finding of frank cerebrovascular disease
- Those who have abnormal lab tests: CBC, Bun, Cr, Electrolytes, LFT, metabolic blood test (Thyroid Function Test, folate, B12, lipid profile, FBS, HbA1c), inflammation/infection blood tests (Syphilis, HIV, ESR)
- Mild dementia patients with abnormal special blood test (autoimmune/paraneoplastic panel, antineuronal IgG, anti-TPO, anti-thyroglobulin)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Alzheimer's dementia at 3 years after detection of mild cognitive impairment & SPECT Brain perfusion SPECT
- Secondary Outcome Measures
Name Time Method MMSE and MoCA score at 3 years MMSE and MoCA neurophyschological tests