A Genomic Analysis of Evolution of Epithelia Ovarian Tumors

• Conditions: Progression-free Survival; Epithelial Ovarian Cancer; Epithelial Ovarian Tumor of Borderline Malignancy; Driving Mutations

• Registration Number: NCT03742388
• Lead Sponsor: Lei Li

Brief Summary

Epithelial ovarian carcinomatous and borderline components sometimes appeared in one patient. This study aims to analyze the genomic patterns of the carcinomatous and borderline components in the ovarian epithelial tissues. These tissues will be collected from paraffin section by microdissection to distinguish normal, carcinomatous and borderline tissues.

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-11
• Study First Submitted: 2018-11-09
• Study Start: 2018-11-10
• Study First Submitted QC: 2018-11-13
• Last Update Submitted: 2018-11-13
• Study First Posted: 2018-11-15
• Last Update Posted: 2018-11-15
• Primary Completion: 2020-12-23
• Study Completion: 2020-12-23

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• Confirmed primary epithelial ovarian borderline tumor with cancer
• Signed an approved informed consents
• Feasible for sampling

Exclusion Criteria

• Not meeting all of the inclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequencies of somatic driving mutations	Two years	The differences of frequencies of somatic driving mutations will be compared between normal, carcinomatous and borderline tissues.

Secondary Outcome Measures

Name	Time	Method
Progression-free survival	Five years	Progression-free survival between patients with differential expressed multi-omics will be compared.

Trial Locations

Locations (1)

Lei Li; 🇨🇳 Beijing, Beijing, China