To evaluate the effect of dexmedetomidine as an anaesthetic adjuvant on optic nerve sheath diameter (ONSD) and central venous pressure (CVP) in patients undergoing elective neurosurgical procedures.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To assess the effect of dexmedetomidine as an anaesthetic adjuvant on optic nerve sheath diameter (ONSD) in adult patients.
研究概览
简要总结
The goals of neuroanesthesia are to ensure stable peri operative cerebral hemodynamics and avoid sudden rise in intracranial pressure to prevent acute swelling. Rised intracranial pressure ice is usually morbidity, mortality, and poor neurological outcomes. Raised intracranial pressure can arise from intracranial SOL and nontraumatic origin.
Monitoring of intracranial pressure therefore becomes necessary in patients
Presenting with the space occupying lesions. Invasive intracranial pressure monitoring is gold standard but it is associated with complications.
The use of bedside ocular ultrasonography in measuring optic nerve sheath diameter can be useful method for defecting raised intracranial pressure.It has the advantage of being a noninvasive,portable and easily preformed approach.
Dexmedetomidine is a highly selective alpha -2 adrenoreceptor agonist recently introduced in anesthesia practice . It produces dose dependent sedation,anxiolytics and analgesia without respiratory depression.
This study is therefore designed to evaluate the effect of Dexmedetomidine as an anesthetiser adjuvant on the size of optic nerve sheath diameter and central venous pressure in elective neurological procedures
The goals of neuroanesthesia are to ensure stable peri operative cerebral hemodynamics and avoid sudden rise in intracranial pressure to prevent acute swelling. Rised intracranial pressure ice is usually morbidity, mortality, and poor neurological outcomes. Raised intracranial pressure can arise from intracranial SOL and nontraumatic origin.
Monitoring of intracranial pressure therefore becomes necessary in patients
Presenting with the space occupying lesions. Invasive intracranial pressure monitoring is gold standard but it is associated with complications.
The use of bedside ocular ultrasonography in measuring optic nerve sheath diameter can be useful method for defecting raised intracranial pressure.It has the advantage of being a noninvasive,portable and easily preformed approach.
Dexmedetomidine is a highly selective alpha -2 adrenoreceptor agonist recently introduced in anesthesia practice . It produces dose dependent sedation,anxiolytics and analgesia without respiratory depression.
This study is therefore designed to evaluate the effect of Dexmedetomidine as an anesthetiser adjuvant on the size of optic nerve sheath diameter and central venous pressure in elective neurological procedures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 15.00 Year(s) 至 60.00 Year(s)（—）
入选标准
- •Written informed consent ASA 1 and 2 Age.
- •60 years Gender -male and female Patients with elective neurosurgical procedures.
排除标准
- •No extended intracranial pressure but increased optic nerve diameter.
- •Optic nerve disease such as optic neuritis , Arachnoid cyst of optic nerve.
- •Anterior orbital or cavernous sinus mass.
- •Known orbital injury or prior ocular surgery.
- •Histroy of allergy to alpha 2 agonists.
结局指标
主要结局
To assess the effect of dexmedetomidine as an anaesthetic adjuvant on optic nerve sheath diameter (ONSD) in adult patients.
时间窗: 10 months
To assess the effect of dexmedetomidine as an anaesthetic adjuvant on central venous pressure (CVP) in adult patients undergoing elective neurosurgical procedures.
时间窗: 10 months
次要结局
- To find the correlation between ONSD and CVP in adult patients undergoing elective neurosurgical procedures.(Documentation of side effects -nausea , vomiting , hypotension, bradycardia,during and after surgery.)