The effect of Selenium supplementation n patients with ulcerative colitis
- Conditions
- lcerative colitis.Ulcerative colitis
- Registration Number
- IRCT20091114002709N51
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Volunteering participation in the study
The definitive diagnosis of injured colitis by using histological methods on mucosal biopsy of the colon, rectum and jejunium by the physician in the mild to moderate phase
The consumer of only one of the 5-amino-salicylic acid Pentasa, mesalazine or asacole), as well as an immunomodulatory drug such as azathioprine (maximum one tablet/d)
age: 18=
30<BMI =18/5
Change in the type and dosage of the drug during the past month
The onset of some diseases such as : autoimmune diseases, cancer, inflammatory and infectious diseases)
Pregnancy or lactation in women or the use of contraceptives
The use of multi-vitamin - Mineral supplements, omega-3, polyphenols and antioxidants during one previous month
The use of cholesterol lowering drugs (statins), NSAIDs, aspirin and diclofenac, antihistamines, anticoagulants, anti-TNF drugs, barbiturates, corticosteroids) during one previous month
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage of patients in clinical remission at the end of treatment, defined as SCCAI score. Timepoint: at baseline and end of study. Method of measurement: [Simple Clinical Colitis Activity Index] Questionnaire.
- Secondary Outcome Measures
Name Time Method Quality of life. Timepoint: at first and end of study. Method of measurement: IBDQ- 9 questionnaire.;Interleukin 17. Timepoint: at baseline and end of study. Method of measurement: ELISA kit.;Interleukin 10. Timepoint: at baseline and end of study. Method of measurement: ELISA kit.;PGC1-a gene expression. Timepoint: at baseline and end of study. Method of measurement: Real Time RT-PCR.;Sirt1 gene expression. Timepoint: at baseline and end of study. Method of measurement: Real Time RT-PCR.