Lactoferrin Efficacy Versus Ferrous Sulfate in Treatment of Patients With Iron Deficiency Anemia
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- comparison of efficacy of lactoferrin versus ferrous sulfate tharapy in treatment of patients with iron deficiency anemia.
研究概览
简要总结
Lactoferrin (Lf) is a mammalian cationic iron binding glycoprotein belonging to the transferrin family which was discovered 70 years ago, and isolated simultaneously from human and bovine milks in 1960. It is widely distributed in all biological fluids and is also expressed by immune cells, which release it under stimulation by pathogens
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 2 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients with iron deficiency anemia from 2 to 15 years old
排除标准
- •Anemia rather than iron deficiency anemia.
- •Family history of blood disease.
- •Patients with thalassemia trait.
- •Patients with chronic illness.
研究组 & 干预措施
ferrous sulfate
Oral ferrous sulfate 3-6 mg/kg of elemental iron/day in divided doses
干预措施: Ferrous Sulfate (Drug)
lactoferrin
Oral bovine lactoferrin (bfl) 100 mg once daily on empty stomach
干预措施: Lactoferrin Bovine (Drug)
combined
combined therapy (both lactoferrin and ferrous sulfate)
干预措施: Lactoferrin Bovine (Drug)
combined
combined therapy (both lactoferrin and ferrous sulfate)
干预措施: Ferrous Sulfate (Drug)
结局指标
主要结局
comparison of efficacy of lactoferrin versus ferrous sulfate tharapy in treatment of patients with iron deficiency anemia.
时间窗: 30 days
Complete blood count will be done before and after therapy to detect the effect of the therapy on serum hemoglobin(g/d)
Comparison of efficacy of lactoferrin versus ferrous sulfate tharapy in treatment of patients with iron deficiency anemia.
时间窗: 30 days
Total serum iron(ug/d) will be done before and after therapy to detect effect of the therapy on total serum iron level (ug/d)
次要结局
未报告次要终点
研究者
Ahmed Gaber Ahmed
pediatrician
Assiut University