The effect of fennel extract on antimullerian hormone and ultrasound criteria in infertile women with Occult premature ovarian failure

Phase 3

Conditions: Occult premature ovarian insufficiency.

Registration Number: IRCT20111219008459N15

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 60

Inclusion Criteria

1) Evidence suggesting occult premature ovarian failure: antimullerian hormone > 1, or reduction of ovarian follicular reserve by transvaginal ultrasound (reduction of antral follicles less than 6 in each ovary)
2) Presence of menstrual cycles
3) Age 20-40 years
4) Having Both ovaries
5) No other causes of female infertility including fallopian tube disorders, endocrine system disorders and uterine disorders, endometriosis, hyperprolactinemia and sexual disorders based on the patient's medical record.
6) Not using complementary herbal medicines in the last three months

Exclusion Criteria

1) Alcohol consumption and smoking
2) Obesity, BMI >30
3) Willingness to use donated eggs
4) Having a history of cancer, radiotherapy and chemotherapy
5) People with ovarian cysts and uterine myoma
6) People being treated with the antibiotic ciprofloxacin (46)
7) Presence of menopause symptoms (hot flashes, night sweats)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of the number of ovarian antral follicles in the group receiving fennel capsules and the control group. Timepoint: At the beginning of the study (before the start of the intervention) 2 months after the start of the intervention. Method of measurement: Real time transvaginal ultrasound with Madison v20 brand, which is made in South Korea.;Comparison of AMH levels in the group receiving fennel capsules and the control group. Timepoint: At the beginning of the study (before the start of the intervention) 2 months after the start of the intervention. Method of measurement: AMH laboratory kit.

Secondary Outcome Measures