Brain Vital Signs M-Score: Point-of-care Monitoring for Motor Recovery After Stroke
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Motor task EEG measures
研究概览
简要总结
The purpose of this study is to investigate brain signals relating to motor function, using electroencephalography (EEG) technology. The aims of the study can be separated into 3 specific study objectives:
- Record EEG data from control participants and individuals with stroke during basic motor tasks and build a database of EEG signals to enable analysis of motor control.
- Apply signal processing algorithms to extract EEG features related to motor control.
- Develop a framework/the motor score (M-Score) that uses the EEG signals, in combination with machine learning approaches, to quantify motor control ability.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age requirements:
- •Younger adult control participants (19-40 years old)
- •Older adult control participants (41-80 years old)
- •Individuals with stroke (19-80 years old)
- •Capacity to follow single stage commands
- •Stroke specific inclusion criteria
- •Upper-limb disability as a result of a stroke (>1 month ago)
排除标准
- •Cognitive difficulties that undermine ability to give informed consent (Montreal Cognitive Assessment (MoCA) score below 23).
- •Severe paralysis such that the participant cannot perform simple movements (such as finger tapping, clicking a mouse, etc.)
- •History of head trauma, a major psychiatric diagnosis, neurodegenerative disorder or substance abuse
结局指标
主要结局
Motor task EEG measures
时间窗: 1 day
While completing EEG scans, participants will be asked to execute simple motor movements. . Study will focus on finger tapping task (with mouse-like button for recording movement timing). Participants will be asked to complete self-paced movements with approximately 10-15 second inter-trial spacing. Recording will occur in two-minute intervals, followed by a rest period, repeated until approximately 40 trials have been collected. Other motor movements, such as flexion of the upper limbs or flexion of the lower limbs, may also be considered. During EEG recordings changes in motor oscillations (alpha, beta, \& gamma range) will be analyzed. During EMG recordings, muscle tonicity/spasticity and functional firing patterns will be analyzed.
Resting state EEG measures
时间窗: 1 day
EEG uses scalp sensors to monitor the brain's electrical activity. EEG sensors are placed on the scalp and passively record neural activity with high time resolution. The principal recording system for this study will be a 32-channel g.Nautilus EEG system (g.tec medical engineering). Secondary recording systems may be used: 8-channel g.Nautilus EEG system (g.tec medical engineering) and 64-channel, high-density BrainAmp EEG system (BrainProducts).Participants will be seated while wearing the EEG cap and asked to sit quietly with either eyes open (with a fixation dot or cross to reduce eye movements) or eyes closed. Resting state recordings will be approximately 5-10 minutes in length.
Imagery task EEG measures
时间窗: 1 day
During EEG recording participants could be asked to engage in mental imagery of motor movements stated above. Here, potential changes in oscillatory patterns in the motor cortex will be measured and detected.
次要结局
- Wolf Motor Function Test(1 day)
- Fugl-Meyer Assessment(1 day)
- Box-and-Block Test(1 day)
- Nine-Hole Peg Test(1 day)