Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis
- Registration Number
- NCT02435992
- Lead Sponsor
- Celgene
- Brief Summary
The purpose of this study is to determine whether RPC1063 is effective in the treatment of Ulcerative Colitis (UC).
- Detailed Description
The trial is composed of 2 periods: Induction and Maintenance. In the Induction Period (IP), patients will be entered into the trial in 2 separate cohorts (Cohort 1 and Cohort 2).Patients from Cohort 1 and 2 in clinical response at the end of the IP will proceed through to the Maintenance Period (MP). Patients from Cohort 1 and 2 who participate in this trial may also qualify to participate in an optional Open-Label Extension (OLE) trial.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1012
- Aged 18 to 75 years (at screening for Cohort 1 and 2)
- UC confirmed on endoscopy
- Moderately to severely active UC (May score 6-12)
- Currently receiving treatment with aminosalisylate, prednisone, or budesonide
- Can be receiving azathioprine, mercaptopurine, or methotrexate, but treatment will be stopped prior to randomization
- Have severe extensive colitis as evidence by:
- Physician judgment that the patient is likely to require colectomy or ileostomy within 12 weeks of baseline.
- Current or recent (within 3 months) evidence of fulminant colitis, toxic megacolon, or bowel perforation.
- Diagnosis of CD, indeterminate colitis, or the presence of fistula consistent with CD or microscopic colitis, radiation colitis, or ischemic colitis
- Clinically relevant cardiovascular conditions or other relevant diseases that could impact the implementation or interpretation of the trial, or put the patient at risk
- History of uveitis or unknown macular edema
- Pregnancy, lactation, or a positive serum β-human chorionic gonadotropin (β-hCG) measured during screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description RPC1063 (Ozanimod) RPC1063 1mg, daily oral administration during Induction and Maintenance periods. Placebo Placebo Daily oral administration during Induction and Maintenance periods.
- Primary Outcome Measures
Name Time Method Percentage of Participants in Clinical Remission at 10 Weeks At 10 Weeks Percentage of participants that are in Clinical remission at 10 weeks
Percentage of Participants in Clinical Remission at 52 Weeks At 52 Weeks Percentage of participants that are in Clinical remission at 52 weeks
- Secondary Outcome Measures
Name Time Method Percentage of Participants With Endoscopic Improvement at 10 Weeks At 10 Weeks Percentage of participants with endoscopic improvement at 10 weeks
Percentage of Participants With Endoscopic Improvement at 52 Weeks At 52 Weeks Percentage of participants with endoscopic improvement at 52 weeks
Percentage of Participants in Clinical Remission at Week 52 Who Were in Remission at Week 10 At 52 Weeks Percentage of participants in clinical remission at week 52 who were in clinical remission at week 10
Percentage of Participants With Clinical Response at 10 Weeks At 10 Weeks Percentage of participants that are in Clinical response at 10 weeks
Percentage of Participants With Mucosal Healing at 10 Weeks At 10 Weeks Percentage of participants with mucosal healing at 10 weeks
Percentage of Participants in Clinical Response at 52 Weeks At 52 Weeks Percentage of participants that are in Clinical response at 52 weeks
Percentage of Participants With Corticosteroid Free Remission at 52 Weeks At 52 Weeks Percentage of participants with corticosteroid free remission at 52 weeks
Percentage of Participants With Mucosal Healing at 52 Weeks At 52 Weeks Percentage of participants with Mucosal Healing at 52 weeks
Percentage of Participants With Durable Clinical Remission at 52 Weeks At 52 Weeks Percentage of participants with durable clinical remission at 52 weeks
Trial Locations
- Locations (371)
Arizona Digestive Health
🇺🇸Sun City, Arizona, United States
Arkansas Gastroenterology, P.A.
🇺🇸North Little Rock, Arkansas, United States
Medical Research Center of Connecticut, LLC
🇺🇸Hamden, Connecticut, United States
Gastroenterology Associates, LLC
🇺🇸Baton Rouge, Louisiana, United States
MHAT 'Sv. Marina', EAD
🇧🇬Varna, Bulgaria
Mercy Research
🇺🇸Springfield, Missouri, United States
Mary Hitchcock Memorial Hospital
🇺🇸Lebanon, New Hampshire, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
Gastroenterology Associates of Orangeburg
🇺🇸Orangeburg, South Carolina, United States
University of Virginia
🇺🇸Charlottesville, Virginia, United States
Instituto DAMIC Fundacion Rusculleda
🇦🇷Cordoba, Argentina
Hospital Italiano de La Plata
🇦🇷La Plata, Argentina
Instituto Medico de la Fundacion Estudios Clinicos
🇦🇷Rosario, Argentina
Imeldaziekenhuis
🇧🇪Bonheiden, Belgium
AZ Maria Middelares
🇧🇪Gent, Belgium
MC Rusemed ltd.
🇧🇬Ruse, Bulgaria
City Clinic UMHAC EOOD
🇧🇬Sofia, Bulgaria
MHAT 'Tokuda Hospital Sofia', EAD
🇧🇬Sofia, Bulgaria
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Cabrini Hospital Malvern
🇦🇺Malvern, Victoria, Australia
Medical University Vienna
🇦🇹Vienna, Austria
City Clinical Hospital No 10
🇧🇾Minsk, Belarus
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
NMTH "Tsar Boris III"
🇧🇬Sofia, Bulgaria
UMHAT 'Tsaritsa Yoanna - ISUL', EAD
🇧🇬Sofia, Bulgaria
Medical Centre "Asklepii", OOD
🇧🇬Dupnitsa, Bulgaria
UMHAT "Kaspela", EOOD
🇧🇬Plovdiv, Bulgaria
Fourth MHAT - Sofia EAD
🇧🇬Sofia, Bulgaria
MC Medica Plus
🇧🇬Veliko Tarnovo, Bulgaria
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
UMHAT 'Sveta Anna' AD
🇧🇬Sofia, Bulgaria
Centre integre de sante et de services sociaux de la Monteregie-Centre - Hopital Charles-Le Moyne
🇨🇦Greenfield Park, Quebec, Canada
The Ottawa Hospital - General Campus
🇨🇦Ottawa, Quebec, Canada
Maastricht University Medical Center
🇳🇱Maastrich, Netherlands
Clinical Hospital Center Osijek
🇭🇷Osijek, Croatia
CHUS - Hôpital Fleurimont
🇨🇦Sherbrooke, Quebec, Canada
Clinical Hospital "Sveti Duh", Clinic of Internal Diseases
🇭🇷Zagreb, Croatia
LTD Coloproctological Center
🇬🇪Tbilisi, Georgia
University General Hospital of Larissa
🇬🇷Larissa Thessaly, Greece
DRC Gyogyszervizsgalo Kozpont Kft
🇭🇺Balatonfured, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont
🇭🇺Budapest, Hungary
Clinical Hospital Center Sestre milosrdnice Clinic of Internal Diseases
🇭🇷Zagreb, Croatia
Clinical Hospital Dubrava, Clinic of Internal Medicine, Department of Gastroenterology
🇭🇷Zagreb, Croatia
LLC Vivamedi
🇬🇪Tbilisi, Georgia
LTD Aversi Clinic
🇬🇪Tbilisi, Georgia
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Clinsante S.C. Osrodek Badan Klinicznych
🇵🇱Bydgoszcz, Poland
Obudai Egeszsegugyi Centrum Kft.
🇭🇺Budapest, Hungary
Somogy Megyei Kaposi Mor Oktato Korhaz
🇭🇺Kaposvar, Hungary
"Pius Brinzeu" County Emergency Clinical Hospital, Department of Gastroenterology and Hepatology
🇷🇴Timisoara, Romania
Clinical Hospital Center Zvezdara Clinic of Internal Diseases
🇷🇸Belgrade, Serbia
FSBIH "Central Clinical Hospital of Russian Academy of Sciences"
🇷🇺Moscow, Russian Federation
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Meir Medical Center
🇮🇱Kfar Saba, Israel
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza
🇭🇺Gyula, Hungary
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Pannonia Maganorvosi Centrum
🇭🇺Budapest, Hungary
"Sfanta Treime" Clinical Municipal Hospital
🇲🇩Chisinau, Moldova, Republic of
"Sf. Arhanghel Mihail" Municipal Clinical Hospital
🇲🇩Chisinau, Moldova, Republic of
Vrije Universiteit Medisch Centrum (VUMC)
🇳🇱Amsterdam, Netherlands
ETZ Elisabeth
🇳🇱Tilburg, Netherlands
PLEJADY Sp. z o.o. (LLC) Medical Centre
🇵🇱Krakow, Poland
Santa Familia Centrum Badan, Profilaktyki i Leczenia
🇵🇱Lodz, Poland
Bucharest University Emergency Hospital, Department of Internal Medicine II
🇷🇴Bucharest, Romania
Craiova County Emergency Clinical Hospital
🇷🇴Craiova, Romania
SBEIHPE Novosibirsk State Medical University
🇷🇺Novosibirsk, Russian Federation
SBEI HPE Rostov State Medical University of the MoH of the RF
🇷🇺Rostov-on-Don, Russian Federation
Private Educational Institution of Higher Education "Medical University "REAVIZ"
🇷🇺Samara, Russian Federation
Trialmed Llc
🇵🇱Piotrkow Trybunalski, Poland
Road Clinical Hospital on Station Irkutsk-Passazhirskiy of OJSC Russian Railways
🇷🇺Irkutsk, Russian Federation
SBIH of Nizhniy Novgorod region " Nizhniy Novgorod Regional Clinical Hospital n.a. N.A. Semashko"
🇷🇺Nizhniy Novgorod, Russian Federation
LLC Medical Company Hepatologist
🇷🇺Samara, Russian Federation
FFSBI "The Nikiforov Russian Center of Emergency and Radiation Medicine"
🇷🇺St. Petersburg, Russian Federation
SPb SBIH Alexandrovskaya City Hospital
🇷🇺St.Petersburg, Russian Federation
Regional Clinical Hospital
🇷🇺Vladimir, Russian Federation
Specjalistyczna Praktyka Lekarska dr med. Marek Horynski
🇵🇱Sopot, Poland
Pavlov First Saint Petersburg State Medical University
🇷🇺Saint-Petersburg, Russian Federation
Clinical Hospital Center Zemun Department of Gastroenterology
🇷🇸Belgrade, Serbia
IBDcentrum s.r.o.
🇸🇰Bratislava, Slovakia
Gastromedic s.r.o.
🇸🇰Nove Zamky, Slovakia
EndoCorp s.r.o.
🇸🇰Trnava, Slovakia
Ivano-Frankivsk City Clinical Hospital #1 Dep of Surgery SHEI Ivano-Frankivsk NMU
🇺🇦Ivano-Frankivsk, Ukraine
GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine
🇺🇦Kharkiv, Ukraine
GASTROMED Kopon, Zmudzinski and Partners Specialist Centre for Gastroenterology and Endoscopy, Spe
🇵🇱Torun, Poland
SBEI HPE "Kazan State Medical University" of the MoH of the RF
🇷🇺Kazan, Russian Federation
Clinical Hospital Center Bezanijska Kosa, Clinic of Internal Medicine
🇷🇸Belgrade, Serbia
Clinical Center of Serbia, Clinic of Gastroenterology and Hepatology, Department of Gastroenterology
🇷🇸Belgrade, Serbia
PRO SANUS, a.s., Poliklinika ProCare Central
🇸🇰Bratislava, Slovakia
General Hospital Djordje Jovanovic Zrenjanin
🇷🇸Zrenjanin, Serbia
Nemocnica s poliklinikou S. Kukuru Michalovce, a.s.
🇸🇰Michalovce, Slovakia
Fakultna nemocnica s poliklinikou F.D. Roosevelta
🇸🇰Banska Bystrica, Slovakia
Slovak Research Center-team member, Sukromna gastroenterologicka ambulancia
🇸🇰Ilava, Slovakia
Gastroeneterologicka ambulancia MUDr. Peter Hegyi, s.r.o.
🇸🇰Malacky, Slovakia
PIGEAS s.r.o.
🇸🇰Martin, Slovakia
RCI Chernivtsi Regional Clinical Hospital Dept of Gastroenterology Bukovinsky SMU
🇺🇦Chernivtsi, Ukraine
Dnipropetrovsk I.I. Mechnykov Regional Clinical Hospital
🇺🇦Dnipropetrovsk, Ukraine
CI of PH Kharkiv CCH #2
🇺🇦Kharkiv, Ukraine
SI Republican Clinical Hospital of the MOHU Dept of Gastroenterology O.O.Bogomolets NMU
🇺🇦Kyiv, Ukraine
CI of Kyiv RC Regional Clinical Hospital #2
🇺🇦Kyiv, Ukraine
Kyiv CCH #8 Dept of Gastroenterology P.L. Shupyk NMA of PGE
🇺🇦Kyiv, Ukraine
Kyiv CCH #18 Dept of Proctology O. O. Bogomolets NMU
🇺🇦Kyiv, Ukraine
Lviv Regional Clinical Hospital
🇺🇦Lviv, Ukraine
Communal City Clinical Hospital of Ambulance, Dept of Therapy #1 D.Halytskyi Lviv NMU
🇺🇦Lviv, Ukraine
CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU
🇺🇦Sumy, Ukraine
MCIC MC LLC Health Clinic
🇺🇦Vinnytsia, Ukraine
CI City Hospital #1
🇺🇦Zaporizhia, Ukraine
Central District Hospital under Zhytomyr District Council
🇺🇦Zhytomyr, Ukraine
Consultants in Gastroenterology, PA
🇺🇸Columbia, South Carolina, United States
Kinston Medical Specialists, PA
🇺🇸Kinston, North Carolina, United States
Concord Medical Group PRIME
🇺🇸New York, New York, United States
Aurora Care Clinic
🇺🇸Costa Mesa, California, United States
Anaheim Clinical Trials
🇺🇸Anaheim, California, United States
Clinical Research of West Florida Inc - Clearwater
🇺🇸Clearwater, Florida, United States
DBC Research, Corp
🇺🇸Pembroke Pines, Florida, United States
Valley View Internal Medicine
🇺🇸Garden Grove, California, United States
Facey Medical Foundation (Parent)
🇺🇸Mission Hills, California, United States
Advanced Research Institute, Inc.
🇺🇸New Port Richey, Florida, United States
Gastrointestinal Biosciences
🇺🇸Los Angeles, California, United States
South Florida Clinical Trials
🇺🇸Hialeah, Florida, United States
Adobe Clinical Research LLC
🇺🇸Tucson, Arizona, United States
University of California San Diego Medical Center
🇺🇸La Jolla, California, United States
Davita Clinical Trials, LLC
🇺🇸Huntington Beach, California, United States
Alliance Clinical Research, LLC
🇺🇸Oceanside, California, United States
Carolinas HealthCare System Digestive Health
🇺🇸Charlotte, North Carolina, United States
OM Research
🇺🇸Lancaster, California, United States
Universal Axon Clinical Research
🇺🇸Doral, Florida, United States
Florida Center for Gastroenterology
🇺🇸Largo, Florida, United States
Advanced Research for Health Improvement
🇺🇸Naples, Florida, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
NY Scientific
🇺🇸Brooklyn, New York, United States
University of Southern California - Keck School of Medicine
🇺🇸Los Angeles, California, United States
Southern California Research Institute Medical Group, Inc.
🇺🇸Los Angeles, California, United States
UCLA Medical Center
🇺🇸Los Angeles, California, United States
Gastro Florida
🇺🇸Clearwater, Florida, United States
Woodholme Gastroenterology
🇺🇸Baltimore, Maryland, United States
Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Ehrhardt Clinical Research, LLC
🇺🇸Belton, Missouri, United States
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Icahn School of Medicine Mount Sinai Beth Isreal
🇺🇸New York, New York, United States
University of Maryland Medical Group
🇺🇸Baltimore, Maryland, United States
Johns Hopkins Clinical Research Network
🇺🇸Baltimore, Maryland, United States
Theia Clinical Research, LLC
🇺🇸Pinellas Park, Florida, United States
Clinical Research Professionals, LLC - Olde Cabin Rd
🇺🇸Saint Louis, Missouri, United States
Gulf Coast Research Group LLC
🇺🇸Houston, Texas, United States
New York University School of Medicine
🇺🇸New York, New York, United States
Charm City Research Group
🇺🇸Towson, Maryland, United States
Spring Gastroenterology
🇺🇸Spring, Texas, United States
PMG Research of Rocky Mount, LLC
🇺🇸Rocky Mount, North Carolina, United States
Brooke-Army Medical Center
🇺🇸Fort Sam Houston, Texas, United States
Long Island Clinical Research Associates
🇺🇸Great Neck, New York, United States
Atlanta Gastroenterology Associates LLC
🇺🇸Atlanta, Georgia, United States
Northwestern University Feinberg Sch of Medicine Division of Gastroenterology
🇺🇸Chicago, Illinois, United States
The Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Texas Digestive Disease Consultants - Southlake
🇺🇸Southlake, Texas, United States
Weill Cornell Medical College
🇺🇸New York, New York, United States
Instituto Medico CER
🇦🇷Quilmes, Argentina
LHSC - Victoria Hospital
🇨🇦London, Ontario, Canada
Monash Medical Centre Clayton
🇦🇺Bentleigh East, Australia
Mater Hospital Brisbane
🇦🇺South Brisbane, Queensland, Australia
Toronto Digestive Disease Associates, Inc.
🇨🇦Vaughan, Ontario, Canada
Centre For Digestive Diseases
🇦🇺Five Dock, New South Wales, Australia
GASTRO JeKa s.r.o.
🇨🇿Klatovy, Czechia
Vojenska nemocnice Brno
🇨🇿Brno, Czechia
DRK Kliniken Berlin Westend
🇩🇪Berlin, Germany
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Universitatsklinikum Ulm
🇩🇪Ulm, Germany
Nemocnice Slany
🇨🇿Slany, Czechia
PreventaMed
🇨🇿Olomouc, Czechia
Toronto Liver Centre
🇨🇦Toronto, Ontario, Canada
Brandon Medical Arts Clinic
🇨🇦Brandon, Manitoba, Canada
Charite - Campus Virchow-Klinikum
🇩🇪Berlin, Germany
UZ Leuven
🇧🇪Leuven, Belgium
UMHAT 'Dr. Georgi Stranski', EAD
🇧🇬Pleven, Bulgaria
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
🇩🇪Luebeck, Germany
ISCARE, a.s.
🇨🇿Prague 9, Czechia
Universitaetsklinikum Freiburg
🇩🇪Freiburg, Germany
CHC - Clinique St-Jospeh
🇧🇪Liege, Belgium
Charite - Universitaetsmedizin Berlin Charité - Campus Benjamin Franklin
🇩🇪Berlin, Germany
UMHAT "SofiaMed", OOD
🇧🇬Sofia, Bulgaria
LHSC - University Hospital
🇨🇦London, Ontario, Canada
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
🇩🇪Mainz, Germany
Royal Prince Alfred Hospital
🇦🇺Camperdown, Australia
Mount Sinai Hospital
🇨🇦Toronto, Ontario, Canada
Clinical Hospital Centre Rijeka
🇭🇷Rijeka, Croatia
LTD Academician N.Kipshidze Central University Clinic
🇬🇪Tbilisi, Georgia
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Universitaetsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Italy
Azienda Socio Sanitaria Territoriale Fatebenefratelli Presidio Ospedale Sacco
🇮🇹Milano, Italy
Fondazione IRCCS Policlinico San Matteo
🇮🇹Pavia, Italy
Universitaetsklinikum Carl Gustav Carus TU Dresden
🇩🇪Dresden, Germany
Medical Care Unit Dachau
🇩🇪Dachau, Germany
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University
🇰🇷Seoul, Korea, Republic of
Hepato-Gastroenterologie HK, s.r.o.
🇨🇿Hradec Kralove, Czechia
Thomayerova nemocnice
🇨🇿Praha 4, Czechia
LTD Research Institute of Clinical Medicine
🇬🇪Tbilisi, Georgia
Complesso Integrato Columbus
🇮🇹Roma, Italy
424th Army General Hospital
🇬🇷Thessaloniki, Greece
Azienda Ospedaliera Universitaria Policlinico Sant Orsola Malpighi
🇮🇹Bologna, Italy
Vasutegeszsegugyi Kft. - Debreceni Egeszsegugyi Kozpont
🇭🇺Letavertes, Hungary
Gregar s.r.o.
🇨🇿Olomouc, Czechia
Institut klinicke a experimentalni mediciny
🇨🇿Praha 4, Czechia
Crohn Colitis Centrum Rhein Main
🇩🇪Frankfurt, Germany
Seoul National University Bundang Hospital
🇰🇷Seongnam, Korea, Republic of
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
CHA Bundang Medical Center CHA University
🇰🇷Seongnam-si,, Korea, Republic of
Laiko General Hospital of Athens
🇬🇷Athens, Greece
General Hospital of Thessaloniki Hippokration
🇬🇷Thessaloniki, Greece
MDM Healthcare Centre
🇵🇱Warsaw, Poland
Azienda Ospedaliero Universitaria San Martino
🇮🇹Genova, Italy
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju-Si, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)
🇮🇹Monza, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano (MI), Italy
Christchurch Hospital NZ
🇳🇿Christchurch, New Zealand
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Wolfson Medical Center
🇮🇱Holon, Israel
Kaplan Medical Center
🇮🇱Rechovot, Israel
Zuyderland Medisch Centrum - Sittard-Geleen
🇳🇱Sittard-Geleen, Netherlands
Specjalistyczna Przychodnia Lekarska Medicus
🇵🇱Chorzow, Poland
LexMedica Osrodek Badan Klinicznych
🇵🇱Wroclaw, Poland
Multidisciplinary Medical Clinic "Anthurium"
🇷🇺Barnaul, Russian Federation
SBIH City Clinical Hospital #31
🇷🇺Saint Petersburg, Russian Federation
SPb SBIH City Hospital # 26
🇷🇺Saint-Petersburg, Russian Federation
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Italy
Clinical Hospital of the Ministry of Health, Department of Endoscopic Surgery
🇲🇩Chisinau, Moldova, Republic of
SOLUMED Centrum Medyczne
🇵🇱Poznan, Poland
KO-MED Centra Kliniczne Staszow
🇵🇱Staszow, Poland
Bacau County Emergency Hospital, Department of Gastroenterology
🇷🇴Bacau, Romania
Dunedin Public Hospital
🇳🇿Dunedin, New Zealand
The Catholic University of Korea, St.Vicent's Hospital
🇰🇷Suwon, Korea, Republic of
Dr MJ Prins Practice
🇿🇦Cape Town, South Africa
Pauls Stradins Clinical University Hospital
🇱🇻Riga, Latvia
Republican Clinical Hospital
🇲🇩Chisinau, Moldova, Republic of
Universitair Medisch Centrum Groningen (UMCG)
🇳🇱Groningen, Netherlands
Dr JP Wright Practice
🇿🇦Cape Town, South Africa
Sf. Apostol Andrei Constanta Emergency Clinical County Hospital
🇷🇴Constanta, Romania
Clinical Center Nis, Clinic of Gastroenterology and Hepatology
🇷🇸Nis, Serbia
Endocare Research
🇿🇦Cape Town, South Africa
BHI of Omsk region "Clinical Oncology Dispensary"
🇷🇺Omsk, Russian Federation
Union Clinic
🇷🇺Saint-Peterburg, Russian Federation
University Hospital of the Canary Islands (HUC) La Laguna
🇪🇸La Laguna, Spain
Alian s.r.o.
🇸🇰Bardejov, Slovakia
University Hospital Germans Trias i Pujol
🇪🇸Badalona, Spain
Central City Clinical Hospital Dept of Theraphy No. 2 SHEI Ivano-Frankivsk NMU
🇺🇦Ivano-Frankivsk, Ukraine
Tiervlei Trial Centre
🇿🇦Cape Town, South Africa
University Hospital Virgen del Rocio
🇪🇸Sevilla, Spain
Si Institute Of Gastroenterology Of Namsu Dept Of Stomach And Duodenum Diseases
🇺🇦Dnipropetrovsk, Ukraine
CI of TRC Ternopil University Hospital
🇺🇦Ternopil, Ukraine
Emmed Research
🇿🇦Pretoria, South Africa
Zaporizhia City Multispecialty Clinical Hospital #9, Department of Neurology
🇺🇦Zaporizhia, Ukraine
Zaporizhia Regional Clinical Hospital
🇺🇦Zaporizhzhia, Ukraine
A. Novak Transcarpathian Regional Clinical Hospital
🇺🇦Uzhgorod, Ukraine
City Clinical Hospital of Emergency and Urgent Care of Zaporizhzhya
🇺🇦Zaporizhia, Ukraine
Gloucestershire Royal Hospital
🇬🇧Gloucester, United Kingdom
The Methodist Hospital Research Institute
🇺🇸Houston, Texas, United States
Benaroya Research Institute at Virginia Mason
🇺🇸Seattle, Washington, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Cotton-O'Neil Clinical Research Center, Digestive Health
🇺🇸Topeka, Kansas, United States
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Medical Associates Research Group, Inc.
🇺🇸San Diego, California, United States
City Medical Group
🇺🇸Miami, Florida, United States
Advanced Clincial Research
🇺🇸Miami, Florida, United States
University of California at San Francisco (PARENT)
🇺🇸San Francisco, California, United States
UC Health Clinical Trials Office
🇺🇸Cincinnati, Ohio, United States
University of Oklahoma
🇺🇸Oklahoma City, Oklahoma, United States
Oregon Health & Science University
🇺🇸Portland, Oregon, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Gastroenterology Research of San Antonio, LLC
🇺🇸San Antonio, Texas, United States
San Antonio Gastroenterology
🇺🇸San Antonio, Texas, United States
University of Utah
🇺🇸Salt Lake City, Utah, United States
Azienda Ospedaliera Universitaria "Federico II"
🇮🇹Napoli, Italy
IRCCS Ospedale Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo FG, Italy
Advanced Pharma Research, Inc
🇺🇸Delray Beach, Florida, United States
Regenerate Clinical Trials
🇺🇸Miami, Florida, United States
Med-Care Research
🇺🇸North Miami Beach, Florida, United States
Center For Digestive Health
🇺🇸Troy, Michigan, United States
Grand Teton Research Group, PLLC
🇺🇸Idaho Falls, Idaho, United States
DM Clinical Research
🇺🇸Oak Lawn, Illinois, United States
Gastro Center of Maryland
🇺🇸Columbia, Maryland, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Community Clinical Research Network
🇺🇸Marlborough, Massachusetts, United States
Commonwealth Clinical Studies, PLLC.
🇺🇸Brockton, Massachusetts, United States
Clinical Research Professionals LLC - The Pines Court
🇺🇸Saint Louis, Missouri, United States
Clinical Research Professionals, LLC - De Paul Medical Dr
🇺🇸Bridgeton, Missouri, United States
Mount Sinai - PRIME
🇺🇸New York, New York, United States
Asheville Gastroenterology Associates, P.A.
🇺🇸Asheville, North Carolina, United States
Hospital of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Digestive Disease Specialists
🇺🇸Oklahoma City, Oklahoma, United States
Baylor Research Institute
🇺🇸Dallas, Texas, United States
Houston Endoscopy and Research Center
🇺🇸Houston, Texas, United States
Digestive Health Specialists of Tyler
🇺🇸Tyler, Texas, United States
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
Hospital Italiano
🇦🇷Buenos Aires, Argentina
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Gomel Regional Clinical Hospital
🇧🇾Gomel, Belarus
Vitebsk Regional Clinical Hospital
🇧🇾Vitebsk, Belarus
MHAT "Lyulin", EAD
🇧🇬Sofia, Bulgaria
Medical Center "Nov Rehabilitatsionen Tsentar", EOOD
🇧🇬Stara Zagora, Bulgaria
Viable Clinical Research - Lindsay
🇨🇦Lindsay, Ontario, Canada
Humber River Hospital
🇨🇦Toronto, Ontario, Canada
Klinikum der Johann Wolfgang Goethe-Universitaet
🇩🇪Frankfurt, Germany
Asklepios Klinik Hamburg
🇩🇪Hamburg, Germany
Universitaetsklinikum Koeln
🇩🇪Koeln, Germany
University General Hospital of Heraklion
🇬🇷Heraklion, Greece
Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz
🇭🇺Bekescsaba, Hungary
Szent Margit Korhaz
🇭🇺Budapest, Hungary
Mohacsi Korhaz
🇭🇺Mohacs, Hungary
SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz
🇭🇺Nyiregyhaza, Hungary
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
🇭🇺Szekesfehervar, Hungary
A.O.U. Policlinico di Modena
🇮🇹Modena, Italy
Konyang University Hospital
🇰🇷Daejeon, Korea, Republic of
Hanyang Univerisy Guri Hospital
🇰🇷Guri-si, Korea, Republic of
Academisch Medisch Centrum
🇳🇱Amsterdam, Netherlands
GLOBE Clinical Research Sp. z o.o. LLC
🇵🇱Klodzko, Poland
Healthcare Center Orkan Med Stec Michalska Spolka Jawna
🇵🇱Ksawerow, Poland
Centrum Medyczne A-Z Clinic
🇵🇱Kraków, Poland
KO-MED Centra Kliniczne Lublin II
🇵🇱Lublin, Poland
Nzoz Vivamed
🇵🇱Warsaw, Poland
Health Centre Metabolic Diseases Outpatient Clinic in Wierzchoslawice
🇵🇱Wierzchoslawice, Poland
Hyperclinica MedLife Grivita
🇷🇴Bucharest, Romania
TVM MED SERV SRL, Medical Center for Gastroenterology, Hepatology and Digestive Endoscopy
🇷🇴Cluj-Napoca, Romania
FSBI "Scientific Research Institute of Physyology and Basic Medicine" under the SB of RAMS
🇷🇺Novosibirsk, Russian Federation
FSMEI HPE "Military Medical Academy n.a. S.M.Kirov"of Ministry of Defense of Russia
🇷🇺Saint-Petersburg, Russian Federation
SBEI HPE "Stavropol State Medical Academy" MoH of RF
🇷🇺Stavropol, Russian Federation
Military Medical Academy, Clinic of Gastroenterology and Hepatology
🇷🇸Belgrade, Serbia
Clinical Center Kragujevac, Clinic of Internal Medicine, Center for Gastroenterohepatology
🇷🇸Kragujevac, Serbia
Gastroped s.r.o.
🇸🇰Kosice, Slovakia
Dr YS Nanabhay Practice
🇿🇦Johannesburg, South Africa
Kyiv City Clinical Hospital #1
🇺🇦Kyiv, Ukraine
Sumy Regional Clinical Hospital
🇺🇦Sumy, Ukraine
M.I. Pyrogov VRCH Dept of Gastroenterology M.I. Pyrogov VNMU
🇺🇦Vinnytsia, Ukraine
Vinnytsia Regional Clinical Hospital for Invalids of the Great Patriotic War
🇺🇦Vinnytsia, Ukraine
Vinnytsia M.I. Pyrohov Regional Clinical Hospital
🇺🇦Vinnytsia, Ukraine
Vinnytsia M.I. Pyrohov National Medical University
🇺🇦Vinnytsia, Ukraine
CI Zapor City Multifunctional CH#9 City Center of Gastroenterology SI Zapor MA of PGE of MOHU
🇺🇦Zaporizhzhia, Ukraine
University Hospital Coventry
🇬🇧Coventry, United Kingdom
Royal Devon and Exeter Hospital (Wonford)
🇬🇧Exeter, United Kingdom
Whipps Cross University Hospital
🇬🇧London, United Kingdom
Royal Shrewsbury Hospital
🇬🇧Shrewsbury, United Kingdom
Hospital Universitario de Gran Canaria Dr. Negrin
🇪🇸Las Palmas de Gran Canaria, Spain
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
EUGASTRO GmbH
🇩🇪Leipzig, Germany
East Carolina Gastroenterology, PA
🇺🇸Jacksonville, North Carolina, United States
Dolphin Medical Research
🇺🇸Doral, Florida, United States
Gastrointestinal Specialists of Georgia, PC
🇺🇸Marietta, Georgia, United States
Harmony Clinical Research
🇺🇸North Miami Beach, Florida, United States
Florida Medical Clinic, P.A.
🇺🇸Zephyrhills, Florida, United States
NSB Research
🇺🇸New Smyrna Beach, Florida, United States
IMIC, Inc.
🇺🇸Palmetto Bay, Florida, United States
Carle Foundation Hospital
🇺🇸Urbana, Illinois, United States
Clinical Inquest Center Ltd
🇺🇸Springfield, Ohio, United States
Ventavia Research Group, LLC
🇺🇸Fort Worth, Texas, United States
Gastroenterology, LTD
🇺🇸Virginia Beach, Virginia, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
Advanced Clinical Research of Miami
🇺🇸Miami, Florida, United States
Indiana University Hospital
🇺🇸Indianapolis, Indiana, United States
Ohio State University Clinical Trials Management Office
🇺🇸Columbus, Ohio, United States
Ewha Womans University Mokdong Hospital
🇰🇷Seoul, Korea, Republic of
University of Louisville
🇺🇸Louisville, Kentucky, United States
University of Michigan Health System
🇺🇸Ann Arbor, Michigan, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
University of Kentucky Medical Center
🇺🇸Lexington, Kentucky, United States
St Thomas' Hospital
🇬🇧London, United Kingdom
Montefiore Medical Center
🇺🇸Bronx, New York, United States