Is Intravesicular Pressure a Better Tool to Predict Renal Failure in Critically Ill Patients Compared With Routine Hemodynamic Parameters?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- High intraabdominal pressure and effect on renal function
研究概览
简要总结
Studies have shown that more than 30% of the overall acute decompensated heart failure (ADHF) patients develop renal dysfunction.
Several studies have tried to find a correlation between hemodynamic Parameters (blood pressure , heart rate, central venous pressure CVP) and worsening of renal function in acute decompensated heart failure patients.
Results showed that there were no correlation between baseline hemodynamics or change in hemodynamics and worsening of renal function.
Another study showed that intra-abdominal pressure (IAP) measuring was a better corollary to renal failure status then measuring cardiovascular hemodynamics using pulmonary artery catheterization in ADHF patients.. An increased IAP was associated with worse renal function and that level of IAP far below abdominal compartment syndrome may adversely affect renal function in patients with ADHF.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any ICU(intensive care unit) or CCU(critical care unit) patient older than 18 y.
- •Patient diagnosed on admission with pulmonary edema/CHF (fluid in the lungs) - independently from the baseline renal function.
- •No subject will be accepted to take part in the study unless they are able to sign or if Health care proxy signs a consent
排除标准
- •Pregnant women
- •Cognitively impaired patients
- •Age<18 yrs old
- •Patients diagnosed on admission with ARDS.
- •Patients admitted with a diagnosis of sepsis ( WBC> 12000, CXR findings consistent with pneumonia, positive blood cultures on admission, UTI)
结局指标
主要结局
High intraabdominal pressure and effect on renal function
时间窗: from admission (baseline) until 72 hours later
IAP measurements will be recorded concomitantly with renal indices. Correlations will be made in regard to pressure measurements and worsening renal function.
次要结局
- Effect of diuretics use on intrabdominal pressure(3 days from admission)
研究者
Suzanne El-Sayegh
Nephrology Attending, Assoc. Chair of Medicine
Northwell Health