Quantification of Fetal Brains' Sulci Along Gestation

• Conditions: Fetal Brain Injury

• Registration Number: NCT03168932
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

Gyrogenesis is an ontogenic process that transforms the smooth (lissencephalic) cortex toward its mature, convolved (gyrencephalic) state. A tortuous, branching and deepening pattern of sulci and fissures outlines for a well-developed cortex.

The aim of this study is to find an algorithm that can detect the sulci in ultrasound images of fetus' brain and measure the length of it. This algorithm can be used for research demands like learning the development of the brain from embryo stages until the birth of the baby

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Study First Submitted: 2017-05-25
• Study First Submitted QC: 2017-05-25
• Study First Posted: 2017-05-30
• Status Verified: 2017-06
• Last Update Submitted: 2017-06-05
• Last Update Posted: 2017-06-07
• Primary Completion: 2017-09
• Study Completion: 2018-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

• Pregnant women between the ages of 18-35
• Gestational age between 25-40 weeks
• Low risk pregnancies

Exclusion Criteria

• Multiple gestation
• Fetal brain abnormality

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
morphological changes of the developing fetal brain	9 months	Ultrasound measurements of the fetal brain sulcation by a computerized algorithm

Trial Locations

Locations (1)

Rambam Health Care Campus; 🇮🇱 Haifa, Israel