Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 128
- Locations
- 1
- Primary Endpoint
- Motor-evoked potentials
Study Overview
Brief Summary
This study aimed to investigate whether concurrent tDCS over the PMC and PNS during action observation enhance observation-execution-related motor cortex excitability and improve motor performance, and to explore the underlying mechanism
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 33 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •normal or corrected-to-normal vision
- •right-handed
Exclusion Criteria
- •pregnancy
- •a history of epilepsy
- •implanted medical devices
- •history or presence of neurological, psychiatric or musculoskeletal disorders, other medical conditions, and left-handedness
Arms & Interventions
tDCS + PNS with action observation
Intervention: tDCS + PNS without action observation (Device)
sham tDCS + sham PNS with action observation
Intervention: sham tDCS + sham PNS with action observation (Device)
tDCS + PNS without action observation
Intervention: sham tDCS + PNS with action observation (Device)
sham tDCS + PNS with action observation
Intervention: tDCS + PNS with action observation (Device)
tDCS + sham PNS with action observation
Intervention: tDCS + sham PNS with action observation (Device)
Outcomes
Primary Outcomes
Motor-evoked potentials
Time Frame: Before interventions, and immediately after interventions
intracortical facilitation assessed by transcranial magnetic stimulation
Time Frame: Before interventions, and immediately after interventions
short-interval intracortical inhibition assessed by transcranial magnetic stimulation
Time Frame: Before interventions, and immediately after interventions
Reaction times of action execution blocks
Time Frame: immediately after interventions
Secondary Outcomes
No secondary outcomes reported