FLuid Responsiveness Prediction Using EXtra Systoles

Not Applicable

Completed

• Conditions: Coronary Artery Bypass Graft

• Registration Number: NCT03002129
• Lead Sponsor: University Medical Center Groningen

Brief Summary

In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload.

Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-12-15
• Study First Submitted QC: 2016-12-20
• Study First Posted: 2016-12-23
• Study Start: 2017-01
• Primary Completion: 2017-06-26
• Study Completion: 2017-09
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-15
• Last Update Posted: 2018-05-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients requiring elective CABG or OPCAB surgery
• Patient's age ≥ 18 years

Exclusion Criteria

• Patient refusal
• Pregnancy
• EF < 35%
• End stage kidney failure (defined by the need for haemodialysis)
• Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
fluid challenge response in stroke volume	during operation	To investigate if post-ectopic induced changes in blood pressure before a fluid bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume

Trial Locations

Locations (1)

Universitu Medical Center Groningen; 🇳🇱 Groningen, Netherlands