FLuid Responsiveness Prediction Using EXtra Systoles
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Coronary Artery Bypass Graft
- Sponsor
- University Medical Center Groningen
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- fluid challenge response in stroke volume
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload.
Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids
Investigators
Prof.dr.T.W.L.Scheeren
prof.dr.
University Medical Center Groningen
Eligibility Criteria
Inclusion Criteria
- •Patients requiring elective CABG or OPCAB surgery
- •Patient's age ≥ 18 years
Exclusion Criteria
- •Patient refusal
- •Pregnancy
- •EF \< 35%
- •End stage kidney failure (defined by the need for haemodialysis)
- •Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)
Outcomes
Primary Outcomes
fluid challenge response in stroke volume
Time Frame: during operation
To investigate if post-ectopic induced changes in blood pressure before a fluid bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume