FLuid Responsiveness Prediction Using EXtra Systoles
- Conditions
- Coronary Artery Bypass Graft
- Interventions
- Other: fluid challenge
- Registration Number
- NCT03002129
- Lead Sponsor
- University Medical Center Groningen
- Brief Summary
In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload.
Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Patients requiring elective CABG or OPCAB surgery
- Patient's age ≥ 18 years
- Patient refusal
- Pregnancy
- EF < 35%
- End stage kidney failure (defined by the need for haemodialysis)
- Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description fluid challenge fluid challenge -
- Primary Outcome Measures
Name Time Method fluid challenge response in stroke volume during operation To investigate if post-ectopic induced changes in blood pressure before a fluid bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Universitu Medical Center Groningen
🇳🇱Groningen, Netherlands
Universitu Medical Center Groningen🇳🇱Groningen, Netherlands