Tinnitus pitch matching by residual inhibition and contrast gain control.

Completed

Conditions: tinnitus
10019243

Registration Number: NL-OMON48700

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Tinnitus group (A, n=20):
- No reported neurological or psychiatric disorders (excluding tinnitus and
hearing loss);
- Chronic tinnitus (lasting more than 6 months);
- Adult, 18-75 years of age;
- Symmetric hearing loss with PTA (average threshold 1000-2000-4000 Hz) >= 30 dB;
- Written informed consent;
Hearing loss group (B, n=20):
- No reported neurological or psychiatric disorders (excluding hearing loss);
- Adult, 18-75 years of age;
- Symmetric hearing loss with PTA (average threshold 1000-2000-4000 Hz) >= 30 dB;
- Written informed consent;
Control group (C, n=20)
- Healthy subjects (i.e., excluding tinnitus, no medical, neurological, or
psychiatric disorders);
- Adult, 18-75 years of age;
- Normal hearing thresholds or mild hearing loss (average threshold <=20 dB @
500-2000 Hz);
- <=30 dB difference between both ears for all the standard audiometric
frequencies;
- Written informed consent;

Exclusion Criteria

- All subjects who cannot fully understand the experimental task.
- Non-conformance to any of the inclusion criteria stated above.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Part I:<br /><br><br /><br>The primary endpoint will be the tinnitus pitch on psychoacoustic responses.<br /><br>These include the following:<br /><br>- Difference between audio samples and automatic method for tinnitus<br /><br>characterization.<br /><br>- Relation between participants* RI function and tinnitus pitch.<br /><br><br /><br>Part II:<br /><br><br /><br>The primary endpoint of this part will be the difference in contrast gain<br /><br>control between tinnitus patients, hearing loss patients and controls. These<br /><br>include the following:<br /><br>- Relation between behavioral measures and EEG responses for the three groups.<br /><br>- Relation between tinnitus pitch and contrast gain control measures for<br /><br>tinnitus patients.</p><br>

Secondary Outcome Measures