The effect of Donepezil and Memantine combinition on treatment of traumatic brain injury
- Conditions
- Traumatic brain injury.other disorders of brain in diseases classified elsewhere
- Registration Number
- IRCT2013041613027N1
- Lead Sponsor
- Research adjutancy ,Guilan university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 162
aphasia patients having post-traumatic cognitive deficit; moderate & severe traumatic brain injury according to GCS at first 24 h; age range between 18-60 years; GOS score 4 & 5; at least 4 years formal education; maximum of aphasia quotient 75 based on P.AD; moderate and severe cognitive deficit(MMSE score<17); post onset discharge time 2-4 weeks(sub-acute phase).
Exclusion criteria: history of neurological disease including CVA, brain tumor, epilepsy, seizure, Parkinson and dementia...; previous brain trauma; history of psychiatric disorder and using of antipsychotic & antidepressant drugs; history of drug abuse and pre-existing verbal and cognitive deficit; exist of deafness and blindness; appearance of drug's side effects; exist of renal disease, heart disease, hypertension and unwillingness for continue of the study.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method