Efficacy of Combined CO2 Fractional Laser With Bimatoprost 0.03% in Treatment of Alopecia Areata
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Hair regrowth
研究概览
简要总结
The goal of this study is to evaluate the efficacy and safety of combined CO2 fractional laser with Bimatoprost 0.03% as novel treatment of alopecia areata.
The main question to study is will the bimatoprost facilitate hair growth if added to fractional CO2 laser treatment in Alopecia areata.
详细描述
The study included 30 patients who were diagnosed clinically and dermoscopically as alopecia areata with age ranged between 16-55 years. The patients are divided into 2 groups: Group I, received fractional laser sessions with immediate and daily Bimatoprost application and Group II, received only frequent Laser sessions. Laser sessions were given to each patch once every 3 weeks, the procedure was repeated for 3 times.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 55 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with alopecia areata of the scalp (multilocuolaris or single patch).
- •Patient aged from 16- 55 years old in both sex.
- •Other treatment wash out period is two months.
排除标准
- •Ophiasis pattern and other patterns of alopecia areata.
- •Chronic diseases of liver, heart, kidney and blood
- •Pregnant women
- •Infections of skin in site of intervention
研究组 & 干预措施
CO2
Each patient received only three CO2 fractional laser sessions 3 weeks apart
干预措施: CO2 fractional laser (Device)
Bimatoprost + CO2
Each patient received three CO2 fractional laser sessions 3 weeks apart with immediate and subsequent daily Bimatoprost 0.03%,1 drop for each 1cm².
干预措施: Bimatoprost 0.03% solution (Drug)
Bimatoprost + CO2
Each patient received three CO2 fractional laser sessions 3 weeks apart with immediate and subsequent daily Bimatoprost 0.03%,1 drop for each 1cm².
干预措施: CO2 fractional laser (Device)
结局指标
主要结局
Hair regrowth
时间窗: 9 weeks
Efficacy of treatment assessed using a prognostic scoring system proposed by Mcdonald Hull and Norris for density, pigmentation, and texture of growing hair. Grade 1 - Regrowth of vellus hair Grade 2 - Regrowth of sparse pigmented terminal hair Grade 3 - Regrowth of terminal hair with patches of alopecia Grade 4 - Regrowth of terminal hair on scalp
次要结局
- Side effects(9 weeks)
- Follow up assessment(9 weeks)
研究者
Ahmed Hassan Nouh MD
Lecturer of Dermatology, Venereology and Andrology department
Al-Azhar University