Exercise Capacity in Congenital Heart Disease: The Role of Muscle Metabolism - Exercise Capacity in Congenital Heart Disease

niversitair Medisch Centrum Groningen0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•Patients with pulmonary arterial hypertension:
•- Between 8 and 18 years of age
•- Diagnosis confirmed at the UMC Groningen
•Patients with a Fontan circulation:
•- Between 8 and 18 years of age
•- Diagnosis confirmed by the UMC Groningen
•- Successfully undergone a Fontan procedure
•- Stable haemodynamic condition
•Patients with tetralogy of Fallot:
•- Between 8 and 18 years of age
•- Diagnosis confirmed by the UMC Groningen
•- Successfully undergone procedure to repair the abnormalities;Healthy subjects between 8 and 18 years of age, without significant cardiac defect or known comorbidity affecting exercise tolerance.;All parents and subjects from 12 y.a.o.:
•Written informed consent

•Patients and controls:
•- age <8 and >18
•- not familiar with the Dutch language
•- ineligible to perform an exercise test
•- with contra-indications for 31P/1H MRS examination
•- (suspected) pregnancy
•- mental retardation
•- with comorbidity affecting exercise tolerance (Anaemia, musculoskeletal injury)
•- being under examination for non-diagnosed disease at the time of investigation
•- with severe complications due to cardiomyopathy/arrhythmia
•- with exacerbation of disease at time of investigation
•- with a pacemaker implanted
•- with severe complications due to epilepsy
•- with musculoskeletal disease (i.e. muscular dystrophy)

发起方