Importance of the Infusion Rate for the Plasma Expanding Effect of 5% Albumin in the Septic Patient
试验速览
- 阶段
- 4 期
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Extravascular lung water (EVLW) before and after fluid resuscitation
研究概览
简要总结
Correction of hypovolemia is an important therapeutic measure，Even though there is no consensus regarding infusion rates, a plasma volume (PV) expander is often given at a fast rate to treat a suspected hypovolemia without delay which can be associated with aggravation of adverse interstitial accumulation of macromolecules and fluid, especially in inflammatory conditions such as sepsis.the smallest possible volumes for PV resuscitation to maintain normovolemia should be used to reduce the risk of simultaneous interstitial fluid accumulation. The investigators tested the hypothesis that a slow infusion rate of a PV expander results in better plasma expansion than a fast infusion rate to patients with severe sepsis or septic shock.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •admitted to the ICU patients with severe sepsis or septic shock (diagnosis according to the 2012 surviving sepsis campaign guidelines)
- •there is low blood pressure (SBP < 90 or mean arterial pressure(MAP) < 65 or the systolic blood pressure is decreased 40 mmHg more than the basic level) or lactic acid or greater for 4 mmol/l
- •the informed consent
排除标准
- •less than 18 years of age
- •more than 80 years old
- •pregnant women
- •albumin allergies
- •the dying patients expected lifetime no more than 24 hours)
- •patient with myocardial infarction, heart failure
- •liver failure
- •refused to sign the informed consent
研究组 & 干预措施
the "bolus" group
10ml/kg of the natural colloid 5% albumin was given at 1 hrs.
干预措施: albumin (Drug)
the"continuous" group
10ml/kg of the natural colloid 5% albumin was given over 6 hrs
干预措施: albumin (Drug)
结局指标
主要结局
Extravascular lung water (EVLW) before and after fluid resuscitation
时间窗: 6 hour
Extravascular lung water （EVLW）is measured by Pulse index continous cardiac output (PICCO) before and after fluid resuscitation in each group
次要结局
未报告次要终点
研究者
rui li
Attending Doctor, critical care medicine department
Hainan People's Hospital