ISRCTN45415158Completed未知
Breath test for patients with acute liver disease for early detection of the need for transplant or recovery: a multicentre non-randomised study
Exalenz Bioscience Ltd (Israel)0 sites30 target enrollmentStarted: February 11, 2010Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 30
Study Overview
Brief Summary
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Adult men or women (greater than 18 years of age)
- •2. Acute liver insult
- •3. No evidence of cirrhosis (unless clinical acute Wilsons)
- •4. International Normalised Ratio (INR) greater than 1.8
- •5. Duration of illness less than 12 or 24 weeks (to be determined [TBD])
Exclusion Criteria
- •1. Any chronic liver disease
- •2. Severe congestive heart failure
- •3. Severe pulmonary hypertension
- •4. Chronic renal insufficiency with severe cardiac disease
- •5. Previous surgical bypass surgery for morbid obesity
- •6. Extensive small bowel resection
- •7. Any autoimmune disorder, which is currently being treated with prednisone or any other immune suppressive medication
- •8. Recipient of any organ transplant
- •9. Proven or suspected hepatocellular carcinoma
- •10. Pregnant
- •11. Allergic to paracetamol (such as Tylenol® or any other related medications)
- •12. History of chronic obstructive pulmonary disease or symptomatic bronchial asthma
- •13. Septic cholestasis
- •14. Currently receiving total parenteral nutrition if they have contraindications to oral drugs
- •15. Taking hepatotoxin drugs
- •16. Hypersensitivity to paracetamol
- •17. Based on the opinion of the investigator, patient should not be enrolled into this study
- •18. Unable or unwilling to sign informed consent
- •19. Participating in other clinical trials evaluating experimental treatments or procedures
Investigators
Similar Trials
Unknown
Not Applicable
Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or RecoveryAcute Liver FailureNCT01435421Hadassah Medical Organization112
Active, not recruiting
Not Applicable
Breath Test for Patients with Acute Liver Disease for early Detection of the Need for Transplant or Recovery - Breath Test for Patients with Acute Liver DiseaseThe study will look at the liver metabolic function in patients with acute liver failure.EUCTR2009-011926-32-GBExalenz Bioscience Ltd112
Completed
Phase 3
Development of a Breath Test for Monitoring Patients With Liver DiseaseCirrhosisFatty LiverNCT00244569Virginia Commonwealth University120
Terminated
Phase 2
Prediction of Severity of Liver Disease by a 13C Octanoate Breath Test (OBT)Metabolic SyndromeNonalcoholic Fatty Liver DiseaseNCT01244503Virginia Commonwealth University61
Recruiting
Not Applicable
Volatile Organic Compounds for the Assessment of Liver DiseaseCirrhosis, LiverFibrosis, LiverHepatocellular CancerHepatocellular CarcinomaCirrhosisNCT04620538Imperial College London500