Observational Study Evaluating the Hemodynamic Relationship Between Volume Removal and Pulse Pressure Variation During Renal Replacement Therapy
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Predictive value of pulse pressure variation for tolerance of fluid removal on CVVHD
研究概览
简要总结
Dialysis is used to control the fluid balance and metabolic state of patients with kidney disease. Control of the metabolic state, via electrolytes, can be monitored using labs that are routinely drawn from patients undergoing continuous hemodialysis. Control of fluid removal is much more difficult. This study aims to determine whether changes in the blood pressure associated with breathing correlate with or predict intolerance to fluid responsiveness with continuous dialysis.
We hypothesize that a measurement of changes in blood pressure with breathing called arterial pulse pressure variation may be able to predict the ability to remove fluid during continuous renal replacement therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 17 years old
- •CVVHD renal replacement therapy
- •indwelling arterial line
排除标准
- •age < 18 years old
- •pregnancy
- •temperature < 34°C
- •severe mechanical ventilator dyssynchrony
- •cardiac arrhythmias precluding automated PPV measurement by ICU monitors
- •non-pulsatile cardiac flow
- •open thoracic cavity
结局指标
主要结局
Predictive value of pulse pressure variation for tolerance of fluid removal on CVVHD
时间窗: Iterative 24 hr periods for the duration of CRRT
次要结局
- Increased doses of vasoactive agents on CRRT(Iterative 24 hr periods for the duration of CRRT)
- Inability to meet goal ultrafiltration rate(Iterative 24 hr periods for the duration of CRRT)
- Hypotensive events on CRRT(Iterative 24 hr periods for the duration of CRRT)