Observational Study of Blood Pressure Measurements and Continuous Dialysis

Terminated

• Conditions: Critical Illness; Kidney Failure; Respiratory Failure; Shock

• Registration Number: NCT01286506
• Lead Sponsor: University of Chicago

Brief Summary

Dialysis is used to control the fluid balance and metabolic state of patients with kidney disease. Control of the metabolic state, via electrolytes, can be monitored using labs that are routinely drawn from patients undergoing continuous hemodialysis. Control of fluid removal is much more difficult. This study aims to determine whether changes in the blood pressure associated with breathing correlate with or predict intolerance to fluid responsiveness with continuous dialysis.

We hypothesize that a measurement of changes in blood pressure with breathing called arterial pulse pressure variation may be able to predict the ability to remove fluid during continuous renal replacement therapy.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2011-01-27
• Study First Submitted QC: 2011-01-27
• Study First Posted: 2011-01-31
• Study Start: 2011-02
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-29
• Last Update Posted: 2016-08-31

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• age > 17 years old
• CVVHD renal replacement therapy
• indwelling arterial line

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Exclusion Criteria

• age < 18 years old
• pregnancy
• temperature < 34°C
• severe mechanical ventilator dyssynchrony
• cardiac arrhythmias precluding automated PPV measurement by ICU monitors
• non-pulsatile cardiac flow
• open thoracic cavity

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Predictive value of pulse pressure variation for tolerance of fluid removal on CVVHD	Iterative 24 hr periods for the duration of CRRT

Secondary Outcome Measures

Name	Time	Method
Increased doses of vasoactive agents on CRRT	Iterative 24 hr periods for the duration of CRRT
Inability to meet goal ultrafiltration rate	Iterative 24 hr periods for the duration of CRRT
Hypotensive events on CRRT	Iterative 24 hr periods for the duration of CRRT

Trial Locations

Locations (1)

The University of Chicago Medical Center; 🇺🇸 Chicago, Illinois, United States