NCT01523028已完成不适用
Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans
Société des Produits Nestlé (SPN)2 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2011年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Sum of plasma areas under the curve of coffee phenolics
研究概览
简要总结
Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 44 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women
- •Aged 20-44 years
- •Caucasian origin
- •Body mass index (BMI) 19-25 kg/m2
- •Used to drinking coffee (similar to study coffee) on a daily basis
- •Being able to tolerate a 48-hour coffee abstinence
- •Normal oral glucose tolerance test
- •Having signed the informed consent form
排除标准
- •Taking medication or dietary supplements
- •Performing a competitive sport
- •Having metabolic disorders
- •Long gut transit time (>24 h)
- •Blood donor
- •Irregularity in menstrual cycle (for women)
- •Pregnancy (for women)
- •Subject who cannot be expected to comply with the study procedures.
- •Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.
结局指标
主要结局
Sum of plasma areas under the curve of coffee phenolics
时间窗: Measurements over 24h after coffee ingestion
次要结局
- Plasma AUC, Cmax and Tmax of individually measured coffee chlorogenic and phenolic acids(Measurements done over 24h after coffee ingestion)
- Urinary excretion of coffee chlorogenic and phenolic acids expressed as % ingested dose(Measurements done over 24h after coffee ingestion)
研究者
研究点 (2)
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