Otogenic Cerebral Sinus Vein Thrombosis in Children: Retrospective Case Series and Associated Thrombophilia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Cultures result
研究概览
简要总结
The aim of this study is to report the clinical presentation, Microbiological, laboratory and imaging evaluation, prothrombotic factors analysis, medical and surgical management and outcomes in children with Otogenic Cerebral Sinus Vein Thrombosis (CSVT).
详细描述
Objective
Otogenic Cerebral Sinus Vein Thrombosis (CSVT) is a rare but serious intracranial complication of otitis media in children. The aim of this study is to report the clinical presentation, Microbiological, laboratory and imaging evaluation, prothrombotic factors analysis, medical and surgical management and outcomes in children with otogenic CSVT. Study design: Retrospective case series
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age of 18 years or younger
- •both sexes are included
- •a clinical or radiological finding of mastoiditis in the patient's file
- •Documentation of CSVT in an imaging study, either CT or MRI.
- •Patient's exclusion criteria
- •age above 18 years
- •lack of a clinical or radiological finding of mastoiditis in the patient's file
- •Lack of documentation of CSVT in an imaging study, either CT or MRI.
- •previous unprovoked venous thromboembolism event.
排除标准
- 未提供
结局指标
主要结局
Cultures result
时间窗: All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee
the results of cultures from blood, ear secretions, surgery samples, and PCR(polymerize chain reaction assay) will be summarized for the percentage of each pathogen and number of positive results from each type of test
Clinical Presentation
时间窗: All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee
Clinical presentation signs and symptoms will be collected and a summary will be represented in a table including all subjects
Morbidity and Mortality
时间窗: All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee
The percentage of Morbidity and Mortality until the end of the follow-up period. Morbidity will include any long term sequelae including permanent neurological deficits, chronic ear inflammation, recurrent mastoiditis, and recurrent thromboembolic events.
Surgical intervention
时间窗: All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee
Summary of all surgical interventions, and determination of the common types of surgery performed.
Thrombophilia evaluation tests
时间窗: All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee
Thrombophilia evaluation test results will be collected and a summary will be represented in a table including all subjects
次要结局
- Imaging Studies results(All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee)
研究者
Kfir Siag
Dr. Siag Kfir
HaEmek Medical Center, Israel