Role of Endocrine Disruptors in Thyroid Cancer

Recruiting

• Conditions: Endocrine Disruptor Chemicals; Thyroid Cancer
• Interventions: Diagnostic Test: Blood and urine diagnostic evaluation

• Registration Number: NCT05747365
• Lead Sponsor: Istituto Auxologico Italiano

Brief Summary

the relationship between human exposure to EDCS and TC is poorly investigated and still unclear. The aim of this study is to evaluate the possible role of old and new generation endocrine disruptors in thyroid cancer. The primary aim is to evaluate the difference in the average levels of the main endocrine disruptors (PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants) between patients with and without a diagnosis of thyroid cancer through highly sensitive, selective and precise mass spectrometry methods, such as liquid chromatography combined with tandem mass spectrometry (LC-MS / MS).

The secondary aim is to evaluate the relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-12
• Study First Submitted: 2023-02-17
• Study First Submitted QC: 2023-02-17
• Study First Posted: 2023-02-28
• Primary Completion: 2023-04-30
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-15
• Last Update Posted: 2024-04-16
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 222

Inclusion Criteria

• patients with a diagnosis of thyroid cancer in the last 5 years (arm A)
• patients without a diagnosis of thyroid cancer will match patients included in arm A

Exclusion Criteria

• subjects under 18 years old
• patients unable to sign the informed consent or questionnaires

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control group	Blood and urine diagnostic evaluation	Patients without clinical diagnosis of thyroid disease
Case group	Blood and urine diagnostic evaluation	Patients with thyroid cancer diagnosis within 5 years before study enrollment

Primary Outcome Measures

Name	Time	Method
Relationship between the concentrations of endocrine disruptors and anamnestic variables	At recruitment	Relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).
Difference in the average levels of the main endocrine disruptors	At recruitment	The main endocrine disruptors evaluated will be PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants

Trial Locations

Locations (1)

Istituto Auxologico Italiano, IRCCS; 🇮🇹 Milan, Italy