Cross-sectional Case-control Study on the Role of Endocrine Disruptors in Thyroid Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 222
- 试验地点
- 1
- 主要终点
- Relationship between the concentrations of endocrine disruptors and anamnestic variables
研究概览
简要总结
the relationship between human exposure to EDCS and TC is poorly investigated and still unclear. The aim of this study is to evaluate the possible role of old and new generation endocrine disruptors in thyroid cancer. The primary aim is to evaluate the difference in the average levels of the main endocrine disruptors (PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants) between patients with and without a diagnosis of thyroid cancer through highly sensitive, selective and precise mass spectrometry methods, such as liquid chromatography combined with tandem mass spectrometry (LC-MS / MS).
The secondary aim is to evaluate the relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with a diagnosis of thyroid cancer in the last 5 years (arm A)
- •patients without a diagnosis of thyroid cancer will match patients included in arm A
排除标准
- •subjects under 18 years old
- •patients unable to sign the informed consent or questionnaires
结局指标
主要结局
Relationship between the concentrations of endocrine disruptors and anamnestic variables
时间窗: At recruitment
Relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).
Difference in the average levels of the main endocrine disruptors
时间窗: At recruitment
The main endocrine disruptors evaluated will be PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants
次要结局
未报告次要终点