Longitudinal and Biological Study of Childhood Disintegrative Disorder
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Pervasive Child Development Disorders
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Enrollment
- 220
- Locations
- 2
- Status
- Terminated
- Last Updated
- 20 years ago
Overview
Brief Summary
OBJECTIVES:
I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.
II. Collect data on molecular genetics of proband and family members.
Detailed Description
PROTOCOL OUTLINE: Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Not specified