Enhancing the perception of pain using virtual reality: a pilot study

Completed

Conditions: Pijn
Pain

Registration Number: NL-OMON50817

Lead Sponsor: Centre for Human Drug Research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 24

Inclusion Criteria

* Healthy male subjects aged 18-40 years, inclusive; healthy is defined as no
clinically relevant abnormalities identified.
* Able to participate and willing to give written informed consent and to
comply with the study restrictions.

Exclusion Criteria

* History of symptoms or any significant including (but not limited to)
neurological or psychiatric disorder., if assessed by the Principal
Investigator as possibly interfering with the study objectives.
* High pain tolerance (80% or higher value for the pain tolerance of the
electrical stair test)
* Presence of Virtual Reality Sickness (simulator sickness).
* Smoker of more than 5 cigarettes per day prior to screening or who use
tobacco products equivalent to more than 5 cigarettes per day.
* Consume, on average, > 8 units/day of (methyl)-xanthines (e.g. coffee, tea,
cola, chocolate) or not able to refrain from use during each stay at the CHDR
clinic.
* Have a urine drug screen detecting illicit drug of abuse (morphine,
benzodiazepines, cocaine, amphetamine, THC, methamphetamines, MDMA) or a
positive alcohol breath test;

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Electrical Stair: PDT (mA), PTT (mA), Area Under the VAS pain Curve (AUC)<br /><br>(mAmm), and post-test VAS (mm).<br /><br> Electrical Stair (including virtual reality simulation without enhancement):<br /><br>PDT (mA), PTT (mA), Area Under the VAS pain Curve (AUC) (mAmm), and post-test<br /><br>VAS (mm).<br /><br> Electrical Stair (including virtual reality simulation with enhancement): PDT<br /><br>(mA), PTT (mA), Area Under the VAS pain Curve (AUC) (mA*mm), and post-test VAS<br /><br>(mm).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Questionnaires on personal characteristics, stress, anxiety and the<br /><br>relationship with electrial pain detection and tolerance thresholds.</p><br>